52 patients <18 years were diagnosed with autoimmune encephalitis, 14 (26.9%) of these tested negative for antibodies. 2 (14%) patients received only steroids, while all others received Steroids plus IVIG. 7 (58%) patients received rituximab for poor response/relapse following Steroids plus IVIG. Of these, 3 (43%) patients further underwent plasmapheresis for presumed refractory AIE. All patients had improvement after plasmapheresis and remained symptom free, including seizure freedom, at 2 year follow up. One patient needed repeat plasmapheresis for presumed relapse. No adverse effects reported.