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Abstract Details

Features of hospitalized pediatric patients with seizures and respiratory viruses: a comparison of SARS-CoV2, other coronaviruses, and influenza
Infectious Disease
S18 - COVID-19: From Bedside and Beyond (1:24 PM-1:36 PM)
003

To compare features of hospitalized pediatric patients with seizures and respiratory viruses.

Neurological symptoms are reported in children with COVID-19, caused by SARS-CoV2. Limited data is available on neurological symptoms in other respiratory viruses, including influenza and other coronaviruses.
Retrospective data was extracted from EPIC on all children between 0-21 years old admitted to Children’s Hospital of Atlanta from January 1, 2014 to June 1, 2021 for seizures and had positive PCR for SARS-CoV-2, other coronaviruses (Coronavirus NL63 and Coronavirus OC34) and influenza (A and B). Patient characteristics including age, race, sex, ethnicity, hospital length of stay, intensive care unit admission, intubation, chest x ray, MRI, and disposition were included. Comparison of patient characteristics between children with COVID-19 and the two other groups were conducted respectively.

A total of 487 pediatric patients were included: 68 COVID-19, 232 influenza, and 187 with other coronaviruses (OC), with median age of 6.2 (interquartile range (IQR): [3.1,11.2]). COVID-19 patients had higher ICU admission rates (50% versus 31%, p = 0.008) but lower intubation rates than OC (19% versus 35%, p = 0.021). Stroke rates were higher in COVID-19 versus OC (6% versus 0.5%, p= 0.019). Initial white blood cell counts were lower in the COVID-19 (median 7.32[6.05, 11.07]) than OC (median 10.66[ 7.61, 14.26]; p = 0.001). The rate of abnormal MRI was lower among COVID-19 patients, compared to OC patients (57% versus 82%) with a medium to large effect size (standard mean difference) of 0.55. However, no differences were observed between COVID-19 and influenza cohorts.

 

Differences in patients with COVID-19 versus other coronaviruses were observed, whereas no differences were observed in COVID-19 versus influenza patients. Vigilance should be undertaken in treatment of children presenting with all respiratory illnesses.
Authors/Disclosures
Monique Anderson, MD, PhD (Mass General Hospital)
PRESENTER 		Dr. Anderson has nothing to disclose.
No disclosure on file
No disclosure on file
No disclosure on file
Grace Gombolay, MD, FÂ鶹´«Ã½Ó³»­ (Emory University/Children'S Healthcare of Atlanta) The institution of Dr. Gombolay has received research support from CDC. The institution of Dr. Gombolay has received research support from NIH. Dr. Gombolay has a non-compensated relationship as a Board of Trustee with National MS Society -Georgia chapter that is relevant to Â鶹´«Ã½Ó³»­ interests or activities.