Â鶹´«Ã½Ó³»­

Â鶹´«Ã½Ó³»­

Explore the latest content from across our publications
Join The Â鶹´«Ã½Ó³»­

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Comparison of Patterns in Resting-State Brain Activity and Functional Connectivity between Amyotrophic Lateral Sclerosis and Behavioral Variant Frontotemporal Dementia
Neuromuscular and Clinical Neurophysiology (EMG)
Neuromuscular and Clinical Neurophysiology (EMG) Posters (7:00 AM-5:00 PM)
037

To examine whether patterns of resting-state brain activity and functional connectivity for cortical and deep brain regions in patients with behavioral variant frontotemporal dementia (bvFTD) resemble those of patients with amyotrophic lateral sclerosis (ALS).

Brain physiological alterations have been described in patients with ALS and bvFTD. Little is known about differences and similarities of patterns of resting-state brain activity and functional connectivity between these disorders. Based on neuropsychological and genetic overlap between ALS and bvFTD, we hypothesize that magnetoencephalography (MEG), as a neurophysiological measure of brain function, may show similar patterns of resting-state brain activity and functional connectivity, in particular in frontal, temporal and deep brain regions.
Eyes-closed resting-state MEG data from 38 ALS patients, 18 bvFTD patients and 18 age- and gender-matched healthy controls (HC) were projected to source-space. Group differences in peak frequency, band-specific relative power and functional connectivity (corrected amplitude envelope correlation) for 78 cortical regions and 12 deep brain regions were determined using the Kruskal-Wallis test and Mann-Whitney U test. False discovery rate was used to correct for multiple comparisons.
There was no difference in peak frequency between the different groups. BvFTD patients, but not ALS patients and HC, showed decreased relative spectral beta power in parietal, occipital, temporal and nearly all deep brain regions. Compared to HC, patients with ALS or bvFTD had an increased alpha 2 (10–13 Hz), theta (4–8 Hz) and delta (0.5–4 Hz) functional connectivity, in the frontal lobe, limbic lobe, deep brain regions, and temporal lobe, respectively.
This MEG study showed that there are similarities in resting-state functional connectivity between ALS and bvFTD patients. MEG was also capable of showing a difference in relative power values in higher frequency bands between the patient groups.
Authors/Disclosures
Rosanne Govaarts, MSc (Amsterdam University Medical Centers)
PRESENTER 		Ms. Govaarts has nothing to disclose.
No disclosure on file
No disclosure on file
Marianne De Visser, MD, PhD (Academic Med Center) Dr. De Visser has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. De Visser has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Argenx. Dr. De Visser has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for AstraZeneca.
Joost Raaphorst, MD (Academic Medical Centre) Dr. Raaphorst has nothing to disclose.
No disclosure on file