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Abstract Details

Effect of REM sleep behavior disorder on neuropsychiatric disturbances in early drug-naïve Parkinson's disease
Movement Disorders
Movement Disorders Posters (7:00 AM-5:00 PM)
067
To determine the severity of neuropsychiatric disturbances in drug-naïve Parkinson’s disease (PD) patients with REM sleep behavior disorder (PD-RBD) and without RBD (PD-NRBD) compared to healthy controls (HC).
Several neuropsychiatric disturbances has been frequently reported in various stages of PD. However, the association between the presence of RBD and the severity of neuropsychiatric symptoms in early stage drug-naïve PD patients is still scarce.
From the Parkinson’s Progression Markers Initiative database, our study recruited 157 HC, 158 PD-RBD, and 262 PD-NRBD. RBD was defined by the cutoff ≥ 5 points on the RBD Questionnaire Score. The severity of neuropsychiatric disturbances was assessed by using the MDS-UPRDS Part I Apathy and Hallucination/Psychosis, the Geriatric Depression Scale Score, the State and Trait Anxiety Score, and the Questionnaire for Impulsive-Compulsive Disorders in Parkinson’s Disease Score.
There was no significant difference in demographic characteristics, duration, and severity of motor symptoms between the PD groups. After adjusting for education, the PD-RBD had higher level of depression and anxiety than the PD-NRBD while the PD-NRBD had more severity of these symptoms than the HC group. Interestingly, only the PD-RBD demonstrated more hallucinations and psychosis than the PD-NRBD and HC group but there was no difference between these PD-NRBD and HC groups. The two PD groups had more severity of apathy than the HC group; however, there was no difference between both PD groups. No difference of impulse control disorder among those three groups.
In drug-naïve PD, the presence of RBD is associated with the more severity of neuropsychiatric disturbances including depression and anxiety. Importantly, our study suggested that RBD is an independent factor accelerating the presence of psychosis even in the early stage of motor symptoms in drug-naïve PD patients. 
Authors/Disclosures
Amputch Karukote, MD
PRESENTER 		Dr. Karukote has nothing to disclose.
Smathorn Thakolwiboon, MD (Mayo Clinic Health System) Dr. Thakolwiboon has nothing to disclose.
Parunyou Julayanont, MD (Department of Neurology, Barrow Neurological Institute) Dr. Julayanont has nothing to disclose.