Abstract Details

Title Understanding Sex-Specific Neuroanatomical Correlation Between Neuropsychological Scores And Higher-Order Diffusion MRI Measures in Parkinson’s Disease

Topic Movement Disorders

Presentation(s) Movement Disorders Posters (7:00 AM-5:00 PM)

Poster/Presentation
Number 057

Objective Understanding a sex-specific neuroanatomical correlation between neuropsychological scores and higher-order diffusion MRI (dMRI) measures derived from diffusion kurtosis imaging (DKI) and neurite orientation dispersion and density imaging (NODDI) in Parkinson’s disease (PD).

Background Recent data suggest that PD-males have significantly greater impairments in executive and processing speed with faster disease progression compared to PD-females. However, the neuroanatomical correlates of such sex-specific neuropsychological differences are unclear.

Design/Methods PD patients (n=37) were recruited at our center, of which 22 patients (Males (M): 16, age: 69.94±6.02 years, disease duration (ddx): 8.4±4.39 years; Females (F): 6, age: 68.5±7.23 years, ddx: 8.23±3.65 years) were diagnosed with mild-cognitive-impairment (MCI) based on expert consensus between neuropsychologists and neurologist using a battery of neuropsychological tests. 15 patients (M: 10, age: 70.4±6.65 years, ddx: 8.2±3.65 years; F: 6, age: 65.4±8.74 years, ddx: 7.4±2.7 years) were diagnosed as PD Cognitively-Normal (PD-CN). Multi-shell dMRI was acquired using: 71 directions each at 3 b-values (b-values: 500s/mm², 1000s/mm², and 2500s/mm²), spatial resolution=1.5mm³, TE=100ms, multiband factor=3. DKI and NODDI measures were estimated and compared to investigate sex and diagnosis-specific WM disorganization using nonparametric statistics. A multiple linear regression model was used to understand the neuroanatomical correlation between higher order dMRI metrics and neuropsychological scores.

Results None of the NODDI measures showed significant difference between the sex and cognitive diagnosis in our PD cohort. However, faster slope of correlation between intracellular volume fraction and letter fluency score was observed in PD-Male-MCI as compared to PD-female-MCI. Axonal kurtosis derived from DKI was found to be higher in PD-Male-MCI as compared to PD-Female-MCI. Furthermore, significant negative correlations were found between symbol digit modality test and axonal water fraction derived from DKI in both male and female PD-MCI but not in PD-CN.

Conclusions Our preliminary findings suggest that certain beyond single tensor dMRI measures correlate with neuropsychological scores in a sex-specific manner.

Authors/Disclosures
Virendra R. Mishra, PhD (The University of Alabama at Birmingham) PRESENTER	The institution of Prof. Mishra has received research support from Keep Memory Alive Young Scholar Award. The institution of Prof. Mishra has received research support from NINDS/NIA: R01NS117547-01. The institution of Prof. Mishra has received research support from NIGMS: P20GM109025.
Aaron Ritter, MD (Cleveland Clinic)	The institution of Dr. Ritter has received research support from NIH.
Zoltan Mari, MD, F�鶹��ýӳ�� (Cleveland Clinic Lou Ruro Center for Brain Health)	Dr. Mari has received personal compensation in the range of $500-$4,999 for serving as a Consultant for AbbVie. Dr. Mari has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for ACADIA. Dr. Mari has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Amneal. Dr. Mari has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Parkinson Study Group. Dr. Mari has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for AbbVie. Dr. Mari has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for ACADIA. Dr. Mari has received personal compensation in the range of $5,000-$9,999 for serving on a Speakers Bureau for US World Meds. Dr. Mari has received personal compensation in the range of $5,000-$9,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Dr. Mari has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Moore and Moore PLLC. Dr. Mari has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Francis Law Firm PLLC. Dr. Mari has stock in NeuroReserve. Dr. Mari has stock in Sensory Cloud. The institution of Dr. Mari has received research support from Cerevel. The institution of Dr. Mari has received research support from AbbVie. The institution of Dr. Mari has received research support from NIH. The institution of Dr. Mari has received research support from Parkinson's Foundation. The institution of Dr. Mari has received research support from Michael J Fox Foundation. The institution of Dr. Mari has received research support from LBDA. The institution of Dr. Mari has received research support from Eli Lilly.
	No disclosure on file
	No disclosure on file

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