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Abstract Details

Age of Onset and Deep Brain Stimulation in a Cohort of Essential Tremor
Movement Disorders
Movement Disorders Posters (7:00 AM-5:00 PM)
018
This study was designed to determine prevalence of deep brain stimulation (DBS) in relation to the age of onset in a cohort of Essential Tremor (ET) patients.

The International Parkinson and Movement Disorder Society tremor task force issued a consensus statement on tremor classification in 2018. The determination of accurate age of onset and rough categorization was proposed based on age groups. Different clinical features, mode of progression, co-morbidities and mortality have been reported for early and late onset ET. DBS is an established treatment for refractory ET. We studied the trend of use of DBS surgery in different age categories.

The Movement Disorders Clinical Case Registry at Parkinson Disease Research, Â鶹´«Ã½Ó³»­ and Clinical Center (PADRECC), Houston, was queried for patients with ICD-9 or 10 diagnostic codes of ET. Subjects were seen in PADRECC from September 1, 2001 - March 31, 2018. Charts were reviewed to verify the diagnosis of ET, surgery for DBS, and the age at onset of symptoms and DBS surgery. Records meeting the inclusion criteria were divided into age groups based on the MDS tremor task force suggestion.
41 patients with ET underwent VIM DBS. 4 patients had unilateral VIM electrode placement while 37 received bilateral. Mean age at the onset of symptoms was 38.71±17.91 years and time of DBS surgery was 68.42±7.8 years. For the age-onset categories, the mean age at the time of surgery was 63.5±3.5 years in childhood group (n=2),  67.25±13.42 years in adolescent group (n=8), 66.46± 5.6 years in early adulthood group (n=15), 70.08± 4.51 years in middle adulthood group (n=12), and 75±3.67 years in late adulthood group (n=4). 
Early adulthood constituted the largest group in this ET cohort who underwent VIM DBS. The mean age at the time of DBS surgery in early adulthood group was less than the adolescent group. 
Authors/Disclosures
Fariha Jamal
PRESENTER 		No disclosure on file
Aliya Sarwar, MD (Baylor College of Medicine/ MEDVAMC) Dr. Sarwar has received personal compensation in the range of $500-$4,999 for serving as a Amneal Fellowship Director Advisory Board Member with Amneal -Rytary.