Â鶹´«Ã½Ó³»­

Â鶹´«Ã½Ó³»­

Explore the latest content from across our publications
Join The Â鶹´«Ã½Ó³»­

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Increases in subthalamic neuronal firing rate and ß frequency neuronal activity in the two hemispheres associated with severity of Parkinson’s disease
Movement Disorders
Movement Disorders Posters (7:00 AM-5:00 PM)
112

To explore whether altered activity in the subthalamic nucleus (STN) is associated with PD severity.


The pathophysiology underlying the asymmetry of motor manifestations in Parkinson’s disease (PD) is unclear.  Abnormal neuronal activity in the basal ganglia is predicted to underlie the mechanisms of parkinsonian motor symptoms.

Thirty patients had single-unit activity in the STN recorded during surgery for bilateral deep brain stimulation. The mean spontaneous firing rate (MSFR), power spectral analysis, and correlations were calculated. Oscillatory activity was compared between the hemispheres. UPDRS III scores were obtained for the body side of initial symptoms, always the more affected side, and the body side of extended symptoms.

 
Results: The MSFR (41.3 ± 11.0 Hz vs 35.2 ± 10.0 Hz, p <0.0001) and the proportion of ß frequency oscillatory neurons (51.3% vs 34.9%, p<0.001) in STN were significantly higher in the body side of initial symptoms. The proportion of tremor frequency oscillatory neurons (34.9% vs 21.4%, p <0.001) was significantly higher in the body side of extended symptoms. The proportion of ß frequency oscillatory neurons correlated with the bradykinesia/rigidity sub-scores across sides (p <0.05); the proportion of tremor frequency oscillatory neurons only correlated with the tremor scores of the body side of extended symptoms (p <0.05).

STN neuronal firing rate is higher and ß oscillatory neurons are more frequent on the side of the brain opposite the more severe bradykinesia. This result is compatible with the rate theory of PD and may be due to loss of dopaminergic input to the striatum. Tremor frequency oscillatory neurons are less pronounced in the STN of the body side of initial symptoms suggesting that ß activity dominates and tremor activity cannot be sustained.

Authors/Disclosures
Ping Zhuang, PhD
PRESENTER 		Dr. Zhuang has nothing to disclose.
Mark Hallett, MD, FÂ鶹´«Ã½Ó³»­ (National Institutes of Health) Dr. Hallett has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Janssen. Dr. Hallett has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Neurocrine. Dr. Hallett has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Brainsway. Dr. Hallett has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for VoxNeuro. Dr. Hallett has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for QuantalX. Dr. Hallett has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier. Dr. Hallett has received intellectual property interests from a discovery or technology relating to health care. Dr. Hallett has received publishing royalties from a publication relating to health care. Dr. Hallett has received publishing royalties from a publication relating to health care. Dr. Hallett has received publishing royalties from a publication relating to health care. Dr. Hallett has received publishing royalties from a publication relating to health care. Dr. Hallett has received personal compensation in the range of $500-$4,999 for serving as a Speaker with International Parkinson and Movement Disorder Society. Dr. Hallett has a non-compensated relationship as a Past-President with Functional Neurological Disorder Society that is relevant to Â鶹´«Ã½Ó³»­ interests or activities.
No disclosure on file
No disclosure on file
No disclosure on file
Yongjie Li (Massachusetts General Hospital) No disclosure on file