Abstract Details

Title Association of Handedness with Cognitive Outcomes in Essential Tremor Patients with Bilateral Deep Brain Stimulation: A Single-Center Retrospective Longitudinal Analysis

Topic Movement Disorders

Presentation(s) Movement Disorders Posters (7:00 AM-5:00 PM)

Poster/Presentation
Number 017

Objective To determine the association of handedness on cognitive outcomes in essential tremor (ET) patients following deep brain stimulation (DBS).

Background DBS is an effective surgical therapy for ET patients suffering from medication-refractory tremor. Multiple contributing factors such as lead location and stimulation parameters may influence neurocognitive outcomes. Few studies have analyzed the role of handedness with these neurocognitive outcomes following DBS placement in ET populations.

Design/Methods A quality assurance review of the DBS clinical database at one institution was used for longitudinal data analysis at five time points (i.e. pre-operative, 3 months, 12 months, 24 months, & 36 months post-operative). We fit a linear mixed-effects model, in which we constructed an intercept-slope model over time for each of the handed groups (right handed & non-consistently right handed [NCRH]). Baseline characteristics of handedness, gender, and years of education were obtained. Primary outcome measures included Controlled Oral Word Association animals/letters (COWAC/COWAL), Trail-making A and B, Mini-Mental Status Exam (MMSE), Dementia Rating Scale (DRS2), and Hopkins Learning Test-Delay Recall (HVLT).

Results One hundred sixty-nine ET patients with a mean age of 79.5±6.4 years, between 2007 to 2020, were included in the analysis. Out of the 169 patients (88 male, 81 female), 141 were right-handers and 28 were NCRH, with an average education of 13.3±3.0 years. Statistical significance was set at p=0.05. COWAC (estimate [e] = -0.25, p=0.91), COWAL (e= 0.18, p= 0.92), Trails A (e= 0.23, p=0.86), Trails B (e= -1.38, p=0.40), MMSE (e= 0.15, p= 0.64), DRS2 (e= -0.01, p=0.97), HVLT (e= 0.25, p=0.91). Comparison between the slopes of the NCRH and right-handers for the primary outcomes included were not statistically significant.

Conclusions Handedness was not associated with cognitive outcomes over 36 months in ET patients post DBS bilateral lead placement.

Authors/Disclosures
Joseph E. Malone, MD (West Virginia University Rockefeller Neuroscience Institute) PRESENTER	Dr. Malone has nothing to disclose.
	No disclosure on file
Elana Farace, PhD	Dr. Farace has nothing to disclose.
	No disclosure on file
Joseph E. Malone, MD (West Virginia University Rockefeller Neuroscience Institute)	Dr. Malone has nothing to disclose.

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Abstract Details