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Abstract Details

Peripheral Immunity in Parkinson’s Disease
Movement Disorders
Movement Disorders Posters (7:00 AM-5:00 PM)
065
We determined whether markers reflecting the balance between innate and adaptive immunity are elevated in individuals with prevalent Parkinson’s disease (PD) and whether these markers are associated with the risk of incident PD.
The immune system plays an important role in the pathophysiological processes involved in PD. However, the temporal relationship between peripheral immune responses and the occurrence of PD remains unknown.  

This study was performed within the population-based setting of the Rotterdam Study. We repeatedly measured blood cell counts and calculated the granulocyte-to-lymphocyte ratio (GLR), platelet-to-lymphocyte ratio (PLR), and systemic immune-inflammation index (SII). We estimated the association between these markers of peripheral immunity and prevalent PD (n = 36) using logistic regression models (n = 8,550). The association between repeatedly measured GLR, PLR and SII and incident PD (n = 65) was studied using joint models (n = 8,425). All models were adjusted for age, sex, smoking, and body mass index.

The mean age (standard deviation) of study participants was 65.4 (10.0) years and 57.9% were women. The GLR, PLR, and SII were associated with prevalent PD. The odds ratio of prevalent PD was 2.47 (95% confidence interval: 1.50-4.05) per doubling of the GLR, 2.30 (1.28-4.14) per doubling of the PLR, and 1.83 (1.20-2.78) per doubling of the SII. During a mean follow-up of 13.9 years, 65 patients were diagnosed with PD. In individuals free of PD at baseline, higher GLR, PLR and SII were not associated with an increased risk of PD. 
We found an association between markers of peripheral immunity and prevalent PD, but did not find an association between these markers and incident PD. These results suggest that the disruption in the balance between the innate and adaptive immune system starts in clinical rather than prodromal PD.
Authors/Disclosures
Lisanne Dommershuijsen (ErasmusMC)
PRESENTER 		Lisanne Dommershuijsen has nothing to disclose.
No disclosure on file
Mohammad Ikram (Erasmus MC) The institution of Mohammad Ikram has received personal compensation in the range of $500-$4,999 for serving as a Consultant for BioGen Inc.
No disclosure on file