Abstract Details

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Abstract Details

Title Postraumatic epilepsy in patients with traumatic brain injury and computed tomography lesions

Topic Epilepsy/Clinical Neurophysiology (EEG)

Presentation(s) Epilepsy/Clinical Neurophysiology (EEG) Posters (7:00 AM-5:00 PM)

Poster/Presentation
Number 079

Objective Analyze factors involved in the risk of developing postraumatic epilepsy.

Background

Traumatic brain injury (TBI) represents between 10 to 20% of all symptomatic epilepsies.

Several factors are associated with risk of developing postraumatic epilepsy (PTE), such as TBI severity, intracranial hemorrhage (its presence and location) and early seizures (ES). The evidence regarding these is, however, limited.

Design/Methods Retrospective analysis of medical records from january/2012 to january/2020 of adult patients (18y/o or more) with TBI and evidence of lesion in computed tomography (CT) with a minimum tracing of 2 years. We defined PTE as the presence of seizures 7 days after TBI. Patients with prior diagnosis of epilepsy, neurological lesions or chronic metabolic diseases were excluded. We performed statistical analysis comparing groups with chi-squared and Fisher tests for categorical variables and parametric and non-parametric methods for continuous variables.

Results 547 medical records were examined. 49 patients were included: 20 with PTE (group A) and 29 without PTE (group B). From group A, 70% presented severe TBI whereas only 38% in group B were severe (p=0,03). 55% from groups A and B presented subdural hematoma. 50% from group A presented intracerebral hemorrhage (ICH) (90% cortical lesions) compared to 34.5% (60% cortical) in group B. 85% of patients in group A required neurosurgical intervention vs 58.6% in group B (p=0,049). 55% of patients in group A received seizure prophylaxis vs 48.3% of group B. We observed 20% of early seizures in group A vs 6.9% in group B (p=0.1). The average time of onset of PTE was 9.7 months after TBI.

Conclusions Severe TBI and neurosurgical intervention were risk factors for developing PTE. These patients had a slightly greater proportion of cortical ICH and ES when compared to the non-epileptic group. We did not observe differences regarding the use of antiseizure prophylaxis and proportion of subdural hematomas.

Authors/Disclosures
PRESENTER	No disclosure on file
Abril Marone, MD (Institute for Neurological Research Raul Carrea. Fleni)	Dr. Marone has nothing to disclose.
Mauricio F. Farez, MD (FLENI)	Dr. Farez has received personal compensation for serving as an employee of Entelai. Dr. Farez has stock in Entelai. The institution of Dr. Farez has received research support from Fundación Sadosky.
	No disclosure on file
	No disclosure on file