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Abstract Details

Quantitative EEG Markers of Hypoglycemia
Epilepsy/Clinical Neurophysiology (EEG)
Epilepsy/Clinical Neurophysiology (EEG) Posters (7:00 AM-5:00 PM)
035
Further exploring Quantitative Electroencephalography (Q-EEG) changes in hypoglycemia
Q-EEG is an increasingly utilized monitoring modality offering the advantage of real-time diagnosis support to clinical teams, as well as for those well trained in EEG but confronted with increasingly high volumes of studies. There are significant correlations between distinct EEG & Q-EEG patterns and clinical conditions. Increase in amplitude, especially of the theta and delta bands, was previously reported with hypoglycemia.

A patient admitted to the Epilepsy Monitoring Unit (EMU) for spell classification, was treated for an unprovoked hypoglycemic event while being on continuous Video-EEG monitoring. EEG was sampled to match glycemic values as entered in the electronic medical record (EMR). Fast Fourier Transform (FFT) was utilized to obtain spectral power of various frequency bands, and (Delta + Theta) / (Alpha + Beta) Ratio (DTABR), Alpha/Delta Ratio (ADR) and Theta/Beta Ratio (TBR) were calculated. These were compared between hypoglycemic and non-hypoglycemic epochs of the recording period.
The theta band power was significantly increased during hypoglycemia (<60mg/dL) compared non-hypoglycemia (>70mg/dL) epochs (R= -0.52; R² =0.27; p =0.006) as previously reported. DTABR and TBR were significantly higher in the hypoglycemia group as well (R =-0.70; R² =0.49; p =0.011) and (R= -0.65; R² =0.43; p= 0.010) respectively. No additional significant differences were recorded.
This study reaffirms theta power correlation with hypoglycemia (p=0.006). Furthermore, this study also demonstrates that DTABR & TBR also significantly correlate with glycemic values (R =-0.70; p=0.011 and R= -0.65; p=0.010 respectively). Additionally, DTABR & TBR variance fit better than theta variance in explaining glycemic value variation (R² = 49% and 43% vs. 27% respectively). Thus, DTABR and TBR may represent more sensitive Q-EEG markers for detection of hypoglycemia than theta band alone. The remarkably high correlation of TDABR with glycemic value (R = -0.7) was not previously reported.
Authors/Disclosures
Sergiu I. Abramovici, MD (Indiana University Health Physicians)
PRESENTER 		Dr. Abramovici has nothing to disclose.
Niravkumar Barot, MD (University of PIttsburgh) Dr. Barot has nothing to disclose.
James F. Castellano, MD, PhD (UPMC Neurology) Dr. Castellano has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Neuro One medical technologies. The institution of Dr. Castellano has received research support from NIH. The institution of Dr. Castellano has received research support from University of Pittsburgh.
Anto Bagic, MD, PhD (UPMC/Univesrity of Pittsburgh) Dr. Bagic has nothing to disclose.
Alexandra Urban, MD, FÂ鶹´«Ã½Ó³»­ (University of Pittsburgh School of Medicine) Dr. Urban has received personal compensation in the range of $0-$499 for serving as a Consultant for Neuropace. Dr. Urban has received personal compensation in the range of $0-$499 for serving as a Consultant for LivaNova.