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Abstract Details

Visual Evoked Potentials Findings In Children Diagnosed With Neurofibromatosis Type 1
Child Neurology and Developmental Neurology
Child Neurology and Developmental Neurology Posters (7:00 AM-5:00 PM)
038
To describe the visual evoked potentials findings in children diagnosed with NF1 but without diagnosis of optic pathway glioma. 
Neurofibromatosis type 1 (NF1) is a common genetic disorder with a birth incidence of at least 1 in 2000. Its main features are diverse and are: cutaneous, ophthalmologic, neurologic and oncologic. The optic pathway glioma (OPG) is the most frecuent brain tumor in this population with a peak incidence at the age of 7 years, this tumor represents a low mortality and high morbidity. The visual evoked potentials (VEP) study represents an objective method for the assessment of the visual pathway function at any age. 
this is a retrospective study, we included pediatric patients referred to Neurophysiology service an the Pediatric Hospital “Dr. Silvestre Frenk Freund” from the Mexican Institute of Social Security from July,2017 to July, 2019. Patiens with diagnosis of OPG were excluded, patients with missing data were eliminated.

A total of 18 pediatric patients diagnosed with NF1 were included, 12 girls and 6 boys with a mean age of 8.4 years (± 5.1). All were assessed trough flash visual evoked potentials (fVEP) using light stimuli with goggles and only 11 patients were able to cooperate with reverse pattern VEP (rpVEP) technique. We decided to analyze each visual pathway (left eye, righ eye) so there were only 34 responses (from 17 patients) in the fVEP test and 22 responses (11 patients) with the rpVEP method. As a main result we measured P100 latency in miliseconds. Almost 40% of visual pathways evaluated trough fVEP demonstrated an abnormal (prolonged) latency with a  mean value of 130.74 ms (9.58 SD). The P100 value in the rpVEP result was normal in 86% (19 of 22 visual pathways). 
The main VEP neurophysiological finding in children with NF1 diagnosis is the delay of P100 response. 
Authors/Disclosures

PRESENTER 		No disclosure on file
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