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Abstract Details

HD-EEG spectra in 6-year-old children born prematurely
Child Neurology and Developmental Neurology
Child Neurology and Developmental Neurology Posters (7:00 AM-5:00 PM)
026
To compare slow brain wave oscillations during wakefulness between 6 year old children born prematurely and children born at term
Premature birth can disrupt crucial brain growth and differentiation with resultant neurodevelopmental consequences. High-density electroencephalography (HD-EEG) is a useful tool to explore brain connectivity and brain-behaviour at the bedside. Delta waves are slow brain waves that represent highly synchronized neuronal activity and are a hallmark of normal deep sleep. Here, they are theorized to have healing, regenerative, and memory consolidating properties. In the awake state, delta waves are thought to only occur with various brain dysfunctions or anti-epileptic drug use, although recent animal and intracranial EEG recordings have challenged this belief.
At UQ Children’s Health Research Centre, 24 children were recruited from the PREBO-6 longitudinal controlled study that examines neurodevelopmental outcomes of 6 year old children born before 31-weeks gestation and compared to 12 controls. HD-EEG monitoring was performed on the same day as neuropsychological assessments. Outcome measures included EEG frequency spectra.
Increased frontal lobe delta wave frequency (0-4Hz) power was seen in the premature cohort when compared to controls during wakefulness (p=.011). Delta wave frequency spectra were not significantly different in other brain regions. EEG spectra in theta wave range were not significantly different (p=.169). Gestational age has a weak positive correlation with degree of delta.
Frontal lobe slow wave oscillations indicating abnormal neuronal hypersynchrony were found in children born before 31 weeks and could contribute to the subtle learning difficulties associated with prematurity. Further research is required to understand its etiology and significance by comparing these findings with structural MRI and neuropsychological data.
Authors/Disclosures
Courtney Nguyen
PRESENTER 		Courtney Nguyen has nothing to disclose.
Kartik Iyer No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
Karen Barlow, MD (University of Calgary) The institution of Dr. Barlow has received research support from Children's Hospital foundation. The institution of Dr. Barlow has received research support from Motor Accident Insurance Commission. The institution of Dr. Barlow has received research support from University of Queensland.