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Abstract Details

Association Between Humidifier Disinfectant Exposure During Infancy and Subsequent Neuropsychiatric Outcomes During Childhood
Child Neurology and Developmental Neurology
Child Neurology and Developmental Neurology Posters (7:00 AM-5:00 PM)
023
The purpose was to determine the association between infant exposure to humidifier disinfectant (HD) with neuropsychiatric problems in pre-school children.
Exposure to humidifier disinfectant (HD) in South Korea — the ‘humidifier disinfectant scandal’ — caused multiple social and health-related problems that are still ongoing. Several previous studies investigated the relationship of HD exposure with lung injury in adults and children. However the long-term prognoses of individuals who were exposed as preschool children are uncertain. This neurodevelopmental period is critical to proper psychological development, so these individuals should be examined from a neuropsychiatric perspective. 
A total of 1199 children (age 4–11 months) were enrolled from the Panel Study of Korean Children (PSKC) study. The Korean version of the Child Behavior Checklist (CBCL) was used for assessments.
Exposure to HD was associated with total neuropsychiatric problems (adjusted odds ratio, aOR = 1.51, 95% CI = 1.12–2.04), being emotionally reactive (aOR = 1.61, 95% CI = 1.03–2.51), having attention problems (aOR = 2.15, 95% CI = 1.19–3.88), and having attention deficit/hyperactivity problems (aOR = 1.59, 95% CI = 1.04–2.43). The risks for being emotionally reactive (aOR = 1.94, 95% CI = 1.09–3.47) and having attention problems (aOR = 2.86, 95% CI = 1.35–6.06) were significantly increased in those exposed to HD for more than 3 months rather than shorter periods.
Exposure to HD during early childhood was associated with subsequent behavioral abnormalities, and duration of exposure was associated with increased risk for certain neuropsychiatric outcomes. The use of HD in this age group should be avoided in light of its association with behavioral abnormalities. Also in children who were exposed, close follow-up of the neuropsychiatric status is warranted, and appropriate intervention should be considered to prevent behavioral problem.
Authors/Disclosures
Sihyeong Park, MD (Mayo Clinic)
PRESENTER 		Dr. Park has nothing to disclose.
Hyunyong Koh, MD, PhD (Texas Children's Hospital) Dr. Koh has nothing to disclose.