Patients with acute ischemic stroke treated with IVT were categorized based on admission LDL-C levels into low, intermediate, and high LDL-C groups (<100/100-130/>130 mg/dl, respectively). Multivariable binary logistic regression analyses were performed to explore the relationships between LDL-C groups and clinical outcomes, including 3-month good outcomes (mRS scores of 0–2) and safety outcomes (symptomatic intracerebral hemorrhage [ICH] and mortality). The interaction between LDL-C groups and prestroke statin use regarding functional outcomes was investigated.

Among 4,711 patients (age, 67±12yrs; male, 62.1%) meeting the eligibility criteria, 42% were in the low LDL-C group, 32% were in the intermediate group, and 26% were in the high group. The low and intermediate LDL-C groups, compared with the high LDL-C group, were not associated with a good outcome at 3 months in multivariable analysis. A potential interaction between LDL-C group and prestroke statin use on 3-month good outcomes was observed (P_interaction=0.07). Among patients with prestroke statin use, low (aOR 1.84 [1.04-3.26]) and intermediate (aOR 2.31 [1.20-4.47]) LDL-C groups were independently associated with a greater likelihood of having a good outcome at 3 months.