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Abstract Details

Moya Moya Disease And Stroke In Pregnancy
Cerebrovascular Disease and Interventional Neurology
Cerebrovascular Disease and Interventional Neurology Posters (7:00 AM-5:00 PM)
258
Stroke prevention in Moya Moya disease (MMD) during pregnancy
MMD, a progressive stenotic vasculopathy, has a stroke incidence of 50-75%; incidence goes up by 34% during pregnancy.

A 25-year-old pregnant woman (first trimester) with bilateral middle cerebral artery (MCA) territory infarcts sustained during childhood due to MMD underwent indirect synangiosis 15 years ago. During her first pregnancy (2018), she developed pre-eclampsia, but no complications related to MMD. Over the past year, prior to current conception, she experienced episodes of right sided numbness concerning for transient ischemic attack (TIA), lasting a few minutes, typically preceded by hyperventilation during anxiety attacks. She underwent CT perfusion (CTP) with acetazolamide challenge showing a relative reduction in perfusion in the left MCA/PCA (posterior cerebral artery) borderzone territory. She presents now with similar TIA symptoms that lasted longer than usual. On evaluation, she was anxious, mildly hypertensive with a normal neurological exam with complete resolution of symptoms. She is compliant with aspirin. Referrals to high-risk obstetrician and behavioral health providers were placed. She was discharged with instructions to continue aspirin, monitor blood pressure (BP) at home and mindfulness techniques to help manage anxiety.

NA
The mainstay of stroke prevention in MMD is surgical revascularization. Our patient’s symptoms are likely TIA from hyperventilation induced vasodilation, supported by the relative hypoperfusion seen on CTP in the left MCA/PCA borderzone. In a non-pregnancy state we would consider surgical revascularization. She is on aspirin monotherapy; dual anti-platelet therapy is not recommended in MMD due to higher risk of hemorrhage. Current management plan is to avoid BP fluctuations and maintain the systolic BP between 110-140 to decrease risk of ischemic and hemorrhagic stroke. This complex case highlights the difficulty in managing MMD cases in hemodynamically labile states like pregnancy. A multidisciplinary approach with high-risk obstetrician and vascular neurology is crucial.
Authors/Disclosures
Preethy Pankaj, MBBS
PRESENTER
Dr. Pankaj has nothing to disclose.
Malveeka Sharma, MD Dr. Sharma has nothing to disclose.