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Abstract Details

Association of MTHFR C677T Gene Polymorphism With Ischemic And Hemorrhagic Stroke in a Northern Indian Population
Cerebrovascular Disease and Interventional Neurology
Cerebrovascular Disease and Interventional Neurology Posters (7:00 AM-5:00 PM)
185
We aimed to study the association of MethylTetraHydroFolateReductase (MTHFR) C 677 -T gene polymorphism with both the Ischemic and Hemorrhagic strokes in our population.

MTHFR C677-T gene Polymorphism is a widely studied genetic mutation all over world not only because of its association with the prevalence of stroke, but also because of the associated hyperhomocysteinemia and potentially preventive nutritional interventions.

We conducted a hospital based case control study with 75 confirmed cases each of Ischemic (ISC) and Hemorrhagic (ICH) strokes against 100 matched controls, and employed the PCR-RFLP technique to study MTHFR C677T Polymorphism.

Among the controls we found the frequency of MTHFR CC, CT and TT genotypes to be 66 (66%), 29 (29%) and 5(5%), while in the ICH cases it was 62(82.66%), 13(17.33%) and 0%; and in the ISC cases it was 57(76%), 18(24%) and 0% respectively. No statistically significant differences in the allelic and genotypic frequencies between ISC patients and controls were found in this polymorphism (p=0.18; OR=0.61; CI=0.31-1.2).  However, the allelic and genotypic frequencies of MTHFR C677T in ICH cases and controls was found to be significantly different (p=0.01; OR=0.40; CI=0.19-0.8).

MTHFR C677T Polymorphism was not associated significantly with ischemic stroke while as in ICH patients it was protective (negatively associated). Furthermore its association with the various clinical parameters of ISC and ICH cases was not found to be significant.

Authors/Disclosures
Sajad A. Tak, Sr., MD (Government Superspeciality hospital)
PRESENTER 		Sajad Tak has nothing to disclose.
Atif R. Kawoosa, MD (M. IDREES RATHER S/O M.RAFIQ RATHER) Dr. Kawoosa has nothing to disclose.