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Abstract Details

Sex Differences in Obstructive Sleep Apnea after Stroke or TIA
Cerebrovascular Disease and Interventional Neurology
Cerebrovascular Disease and Interventional Neurology Posters (7:00 AM-5:00 PM)
175

To evaluate sex differences in patients with post-stroke/TIA obstructive sleep apnea (OSA) with regards to functional outcomes and clinical manifestations of OSA.

OSA is common after stroke/TIA and, if left untreated, is associated with poor outcomes such as decreased functional recovery and recurrent stroke. The current literature suggests that males tend to have more severe OSA compared to females. However, it remains unclear as to whether there are sex differences in post-stroke/TIA OSA with regards to clinical manifestations and its impact on functional recovery.

Patients were selected from three previously conducted studies and were included if they 1) sustained a stroke or TIA, and 2) underwent either a diagnostic in-laboratory polysomnography or home sleep apnea test within one year of their stroke/TIA that demonstrated OSA (apnea-hypopnea index [AHI] ≥5). Linear regression models were used to evaluate study outcomes.
178 participants with post-stroke/TIA OSA (121 males [68.0%] and 57 females [32.0%]) were included. Female sex was the only independent predictor for initial stroke severity (NIHSS) (B= -1.064, p= 0.034) and for greater post-stroke/TIA functional impairment (mRS) (B= -0.575, p=0.011). Female sex (B= -3.529, p= 0.048) and lower age (B= -0.141, p= 0.025) were independent predictors for increased post-stroke/TIA depressive symptoms. Male sex (B= 1.039, p= <0.01) and BMI (B= 0.066, p= <0.01) were independent predictors of a greater STOP-Bang score.
Women with post-stroke/TIA OSA have more severe strokes and poorer functional outcomes compared to men, despite having lower OSA severity. Women with post-stroke/TIA OSA also present atypically, in that they do not score high on predictive scales, such as the STOP-Bang, and exhibit more depressive symptoms. This study reveals that there needs to be a lower index of suspicion for OSA in females who have sustained a stroke/TIA, and that women with post-stroke/TIA tend to do more poorly compared to men.
Authors/Disclosures
Laavanya Dharmakulaseelan, MD
PRESENTER 		Ms. Dharmakulaseelan has nothing to disclose.
Sandra E. Black, MD, FÂ鶹´«Ã½Ó³»­ (Sunnybrook Health Science Center) Dr. Black has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Hoffmann-La Roche. Dr. Black has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen. Dr. Black has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Hoffmann-La Roche. Dr. Black has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Biogen. Dr. Black has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eisai Limited . Dr. Black has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Eli Lilly. Dr. Black has received personal compensation in the range of $10,000-$49,999 for serving on a Speakers Bureau for Biogen. The institution of Dr. Black has received research support from Hoffmann-La Roche. The institution of Dr. Black has received research support from Biogen. The institution of Dr. Black has received research support from GE Healthcare. The institution of Dr. Black has received research support from Eli Lilly. The institution of Dr. Black has received research support from Genentech. The institution of Dr. Black has received research support from NovoNordisk. The institution of Dr. Black has received research support from UCB Biopharma. The institution of Dr. Black has received research support from Alkahest Inc. The institution of Dr. Black has received research support from University of Southern California - AHEAD 3-45 Study.
Richard H. Swartz, BSc MD PhD FRCPC (Sunnybrook Health Sciences Centre) The institution of Dr. Swartz has received research support from Heart and Stroke Foundation of Canada. The institution of Dr. Swartz has received research support from Ontario Brain Institute.
Brian J. Murray, MD, FÂ鶹´«Ã½Ó³»­ The institution of Dr. Murray has received research support from Wake Up Narcolepsy. Dr. Murray has received publishing royalties from a publication relating to health care.
Mark I. Boulos, MD, FRCPC, CSCN(EEG), MSc (Sunnybrook Health Sciences Centre) Dr. Boulos has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Precision AQ. Dr. Boulos has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Takeda. Dr. Boulos has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Techspert. Dr. Boulos has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Sleep Medicine (journal). The institution of Dr. Boulos has received research support from Canadian Institutes of Health Research. The institution of Dr. Boulos has received research support from RLS Foundation. The institution of Dr. Boulos has received research support from Temerty Centre for AI Research and Â鶹´«Ã½Ó³»­ in Medicine (T-CAIREM). The institution of Dr. Boulos has received research support from Heart & Stroke Foundation of Canada. The institution of Dr. Boulos has received research support from Alternative Funding Plan from the Academic Health Sciences Centres of Ontario. The institution of Dr. Boulos has received research support from StrokeCog. The institution of Dr. Boulos has received research support from McLaughlin Centre for Molecular Medicine . The institution of Dr. Boulos has received research support from Zoll Itamar. The institution of Dr. Boulos has received research support from Toronto Dementia Research Alliance. Dr. Boulos has received personal compensation in the range of $500-$4,999 for serving as a Speaker with Jazz Pharmaceuticals. Dr. Boulos has received personal compensation in the range of $500-$4,999 for serving as a Speaker with Lundbeck.