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Abstract Details

Western Diet Associated with More Post-Stroke Depressive Symptoms
Cerebrovascular Disease and Interventional Neurology
Cerebrovascular Disease and Interventional Neurology Posters (7:00 AM-5:00 PM)
199

Examine the association of a Western dietary pattern with depressive symptoms over time among stroke survivors from a community cohort.

Depression is common after stroke. Studies suggest a healthy diet reduces depressive symptoms, but it is not known if this effect is also seen in stroke survivors.

86 participants from an observational prospective cohort study with a history of stroke at their baseline enrollment were included. Participants with missing or invalid baseline dietary evaluations, or fewer than two depression assessments were excluded. Depressive symptoms were assessed annually with a 10-item version of the Center for Epidemiologic Studies Depression scale. Depression was defined as the presence of four or more depressive symptoms. Diet scores were computed using a validated food frequency questionnaire at baseline. Western diet score was computed based on principal component analysis of reported intakes among these participants of 144 food items; higher scores represent high consumption of red meat, refined grains, snacks, and sweets. Western diet score was modeled in tertiles. A generalized estimating equation (GEE) model was performed for the longitudinal analysis of depression as a binary outcome (CESD 0-3 items = 0, >/=4 = 1), with adjustments made for age, sex, education, caloric intake, social activity, use of anti-depressants, and cardiovascular conditions.

Mean age of study participants was 82 ± 7.17 years, with 14.42 ± 2.61 years of education, and 82.56% female. The Western diet score was positively associated with depressive symptoms over time (Diet score Tertile3 vs. Tertile 1:β = 0.22, SE=0.09, p=0.02;  p for trend = 0.022). Interaction for sex suggested a stronger effect in females.

A healthy diet may reduce post-stroke depressive symptoms, with possible sex differences. A diet intervention trial may be needed to determine the optimal nutritional components for prevention of post-stroke depressive symptoms and optimization of brain health.
Authors/Disclosures
Laurel J. Cherian, MD, FÂ鶹´«Ã½Ó³»­ (Rush University Medical Center)
PRESENTER 		The institution of Dr. Cherian has received research support from NIH.
Puja Agarwal, PhD, MBA (Rush University Medical Center) Dr. Agarwal has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Advocate Health. The institution of Dr. Agarwal has received research support from NIH/NIA.
No disclosure on file
No disclosure on file
Julie A. Schneider, MD, MS (Rush Alzheimer'S Disease Center) Dr. Schneider has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Eli Lilly. Dr. Schneider has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for alnylam. Dr. Schneider has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for apellis. Dr. Schneider has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for National Hockey League. The institution of Dr. Schneider has received research support from NIH. Dr. Schneider has received personal compensation in the range of $500-$4,999 for serving as a scientific advisor with Fondation Alzheimer, France.
Neelum T. Aggarwal, MD (Rush Alzheimer's Disease Center) Dr. Aggarwal has nothing to disclose.