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Abstract Details

The Scope and Burden of Agitation, Aggression and Related Symptoms (AARS) in Alzheimer's Patients
Aging, Dementia, and Behavioral Neurology
Aging and Dementia Posters (7:00 AM-5:00 PM)
083
To understand the overlap between AARS with other behavioural symptoms in Alzheimer’s disease, and their impact on requirement for care, burden of care and resource utilisation.
Behavioural symptoms are experienced by ≥90% of patients with dementia at some point in their disease. Patients with AARS may experience other behavioural symptoms, although AARS places particularly high burden on caregivers and the healthcare system.
Data were taken from the 2016 Adelphi Real World Dementia Disease Specific Programme™, a cross-sectional survey of physicians, patients and caregivers in Europe and the US. Physician completed patient record forms captured demographics, clinical characteristics, care requirement and resource utilisation. Caregivers self-completed forms containing the EuroQoL 5-dimension 3-level (EQ-5D-3L), the Visual Analogue Scale (EQ-5D VAS) and the Zarit Burden Interview (ZBI). 2966 patients were identified based on the presence of aggression, disinhibition/impulsivity, agitation, irritability/lability, elation/euphoria (AARS). 2637 patients were classified based on presence of other behavioural symptoms but with no AARS (Other behavioural). 1417 patients had no AARS and no behavioural symptoms (NONE).
AARS patients were more likely to be severe (23% vs 10% and 5%) compared with Other behavioural and NONE group, respectively. Mood-related symptoms were higher in the Other behavioural (78%) vs the AARS (60%) group. AARS was associated with higher: need for caregiver support (90% vs 80% vs 66%), weekly hours of care (25.9 vs 13.3 vs 9.1), overall impairment to caregiver work (31% vs 27% vs 19%), ZBI score (40.7 vs 35.2 vs 29.2), annual hospitalisations (0.6 vs 0.5 vs 0.3), lower caregiver EQ-5D VAS (72.2 vs 76.0 vs 77.7), compared to Other behavioural or NONE group respectively.
Results suggest patients with AARS place increased burden on caregivers and the healthcare system. There is an unmet need for interventions that address AARS. Future studies using multivariate analysis are required to confirm findings.
Authors/Disclosures
Rezaul Khandker
PRESENTER 		Rezaul Khandker has received personal compensation for serving as an employee of Merck & Co., Inc.. Rezaul Khandker has stock in Merck & Co., Inc..
Farid Chekani, PhD (Merck & Co. Inc) Mr. Chekani has received personal compensation for serving as an employee of Merck & Co., Inc..
Farid Chekani, PhD (Merck & Co. Inc) Mr. Chekani has received personal compensation for serving as an employee of Merck & Co., Inc..
No disclosure on file
Emily Trenholm No disclosure on file