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Abstract Details

On the Move: Changes in Motor Activity Level in Individuals with Frontotemporal Dementia
Aging, Dementia, and Behavioral Neurology
Aging and Dementia Posters (7:00 AM-5:00 PM)
029
To elucidate the neuroanatomic basis of new onset motor hyperactivity and hypoactivity in patients with frontotemporal dementia.
Extreme changes in motor activity are often observed in FTD. It remains unclear why some individuals become motorically hyperactive versus hypoactive. The focal, yet heterogeneous atrophy patterns associated with the clinical subtypes of FTD offer an opportunity to delineate brain regions associated with motor changes.
Eighty-eight patients meeting consensus criteria for probable bvFTD, semantic variant PPA, or non-fluent PPA were categorized based on the earliest reported change in motor activity as: hyperactive, hypoactive, or no change. Atrophy patterns from clinical MRI scans at presentation were independently classified as: frontal predominant, temporal predominant, frontal and temporal, or none. Cortical thickness and subcortical volumes were compared for hyperactive vs. hypoactive groups in 35 patients with available scans.
Hyperactivity was prevalent among behavioural (63.4%) and semantic (72.2%) FTD subtypes while hypoactivity was less common in both subtypes (24% and 17% respectively). The majority of non-fluent patients showed no change in motor activity (66.7%). The proportion of hyperactive individuals with predominant temporal lobe atrophy (86.4%) was significantly greater than that of those with frontal lobe atrophy (33.3%; no association with atrophy laterality was found). A model consisting of bilateral frontal, right temporal, and subcortical areas including the basal ganglia explained 33% of the variance, and accurately classified 74.3% of participants within their activity group membership.

The association of the semantic variant and temporal predominant atrophy with motor hyperactivity indicate that changes in the temporal lobe underlie the emergence of hyperactivity in FTD. Hypoactivity was less common and was largely found in patients with frontal predominant atrophy. The volumetric results indicate that changes in the right temporal lobe, frontal regions and basal ganglia are predictive of changes in motoric activity patterns in FTD.
Authors/Disclosures
Carolina R. Silveira, PhD (Parkwood Institute)
PRESENTER 		Carolina Silveira has nothing to disclose.
No disclosure on file
No disclosure on file
Elizabeth Finger, MD, FÂ鶹´«Ã½Ó³»­ Dr. Finger has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Vigil Neuro. Dr. Finger has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Denali Therapeutics. The institution of Dr. Finger has received research support from CIHR. The institution of Dr. Finger has received research support from Physician Servcices Incorporated. The institution of Dr. Finger has received research support from Weston Foundation. Dr. Finger has received personal compensation in the range of $500-$4,999 for serving as a Annual Meeting Course Director with Â鶹´«Ã½Ó³»­.