Abstract Details

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Abstract Details

Title Saccadic Latencies in Progressive Supranuclear Palsy

Topic Neuro-ophthalmology/Neuro-otology

Presentation(s) P9 - Poster Session 9 (12:00 PM-1:00 PM)

Poster/Presentation
Number 5-010

Objective

To assess saccadic latencies in Progressive Supranuclear Palsy (PSP).

Background

Saccadic latency to novel stimuli is typically between 180-200 msec. With a gap paradigm (introduction of a temporal gap between extinguishing the fixation target and saccade target appearance), some individuals generate express saccades (ES) with shorter latencies (85-130 msec). The superior colliculus (SC) rostral pole plays a role in fixation release and, thus, in ES generation. In monkeys, SC lesions eliminate ES. Given SC involvement in PSP, we hypothesized that latencies will be longer in PSP patients and ES less frequent than in healthy individuals.

Design/Methods

Participants performed pro- and gap- saccade sequences. Eye movements were recorded with EyeLink 1000+ video-oculography.

Results Eleven participants with PSP (mean age 68+/-8 years) and eleven healthy controls (mean age 66+/-6 years) were included. Pro- and gap- vertical saccadic latencies were longer in PSP than control participants (pro:314.8+/-121.5 versus 216.7+/-69.1 msec,p=0.0001; gap:300.6+/-108.1 versus 193.4+/-65.2,p=0.003). There were no clear differences in ES generation between the two groups (horizontal: 28% and 29% of saccades in control and PSP; vertical: 16% and 17% of saccades in control and PSP), although PSP patients generated saccades with overall longer latency distributions than controls in both the horizontal and vertical dimensions. Latencies were substantially longer in the vertical than horizontal dimension in controls (difference of: 16 msec, p=0.06), and this difference was exaggerated in PSP (difference of: 100 msec, p=0.003).

Conclusions Saccadic latency prolongation is seen in PSP compared to healthy controls, especially for vertical saccades. This may reflect SC or frontal lobe involvement. However, reduced generation of ES was not seen, suggesting retained albeit impaired SC function in this PSP cohort. Future studies with correlation of saccadic latency to disease severity will determine if ES generation, along with impairment in timing, is lost with disease progression.

Authors/Disclosures
Scott Grossman, MD (New York University, Langone Health) PRESENTER	Dr. Grossman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Acuta Pharmaceuticals.
	No disclosure on file
	No disclosure on file
John-Ross Rizzo	No disclosure on file
Janet C. Rucker, MD	Dr. Rucker has nothing to disclose.