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Abstract Details

How Microcephaly Related to Zika Virus is Impacting on Brazilian Infant Mortality Rates?
Global Health and Neuroepidemiology
P9 - Poster Session 9 (12:00 PM-1:00 PM)
13-010

To define the Zika Syndrome (ZS) perinatal case fatality rate (PCF) since the 2015 Zika outbreak in a Brazilian northeast state highly impacted by the virus.
In 2019 the Infant mortality in Brazil has increased for the first time in 26 years.
Cross-sectional study conducted using data obtained through the State Health Department for cases of microcephaly (MCF) in Rio Grande do Norte State (RN) from April 2015 to March 2, 2019. PCF was defined as the number of deaths as a fraction of the number of sick persons with the specific disease (×100).
There were 535 reported cases of MCF and other CA reported: 4 in 2014, 337 in 2015, 157 in 2016, 21 in 2017, 14 in 2018, and 2 to date in 2019. Of these, 151 were confirmed and 135 remain under investigation. The remaining 247 cases were ruled out by normal physical exams or due to non-infectious cause of MCF. Of the total confirmed cases, 35.8% (54/151) died after birth or during pregnancy. Zika virus infection during pregnancy was confirmed in 55.5% (30/54) of deaths and 1.8% (01/54) had a positive TORCH blood test. The odds ratio for the Zika PCF was found to be 1.5789 (95% CI: 0.7940-3.1398; P = 0.1928). Deaths related to Zika were confirmed using a combination of clinical and epidemiological findings paired with either radiological information or molecular/serological data (RT-PCR and/or IgM/IgG antibodies against Zika). 12 cases remain under investigation and 7 were ruled out as MCF.
The real prevalence might be higher due to the underreporting and lack of resources for confirmatory diagnostic tests (laboratory and imaging). This study indicates that Zika virus accounted for a substantial proportion of MCF cases seen during the years studied, and suggests that ZS contributed to an increase of infant mortality in Brazil.
Authors/Disclosures

PRESENTER 		No disclosure on file
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