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Abstract Details

Allelic Variants of PAX5 and MEF2C-AS2 Genes are Associated with Depression in Temporal Lobe Epilepsy
Epilepsy/Clinical Neurophysiology (EEG)
P8 - Poster Session 8 (8:00 AM-9:00 PM)
12-002
To test whether SNPs previously associated with risk for major depression are also risk factors for depression in patients with temporal lobe epilepsy (TLE). 
Depression is one of the most frequent psychiatric comorbidity in epilepsy, worsens quality of life and adding considerable morbidity to these patients. Recent studies have associated genetic characteristics with depression and with depression in epilepsy.
This is a genetic association study with 160 TLE patients. We tested whether 14 independent SNPs previously associated with risk for major depression were also risk factors for depression associated with (TLE). All patients had detailed medical variables analyzed and were submitted to Structured Clinical Interview for DSM-IV (SCID) for evaluating depression. All subjects were genotyped by TaqMan® SNP genotyping assays in a Real-Time PCR System.
The mean age of TLE patients was 44.5 (SD=12.4) years; 107 patients (66.9%) were females. Depression occurred in 102 (63.7%) patients. Variants in rs7044150, rs8025231, rs12065553, rs2422321, rs1475120, rs1518395, rs1656369, rs4543289, rs10514299, rs2125716, rs2179744 and rs10786831 polymorphisms were not associated with depression in patients. The frequency of the G allele in the rs6476606 and of the C allele in the rs454214 were higher in patients with TLE with depression (p=0.013 and p=0.030). After logistic regression, independent risk for depression in TLE were female sex (O.R.=0.4; 95%CI=0.2-0.9;p=0.03), CC genotype in rs454214 (O.R.=2.4; 95%CI=1.1-5.4.0; p=0.028) and GG genotype in rs6476606 (O.R.=2.5; 95%CI=1.2-5.0.0; p=0.012).
The biological effect of allelic variations rs454214 (upstream of MEF2C gene) and rs6476606 (PAX5 gene) in these SNPs are unknown. Variations in these SNPs have been associated with risk for Major Depression. Our results suggest that allelic variants of these genes might be also independent risk factors for development of depression in TLE. If confirmed, our study might help to elucidate the common variant genetic architecture of depression in epilepsy.
Authors/Disclosures
Marino Bianchini
PRESENTER 		No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file