Abstract Details

Title Effect of Cognitive Reserve on Structural and Functional MR Imaging Measures in Adult Healthy Subjects

Topic Aging, Dementia, and Behavioral Neurology

Presentation(s) P8 - Poster Session 8 (8:00 AM-9:00 AM)

Poster/Presentation
Number 10-002

Objective To investigate the effect of cognitive reserve (CR) on structural and functional MRI networks in young-adult healthy subjects (HS).

Background Early and recurring involvement of cognitive abilities and the exposure to leisure activities during early-life experiences is a requirement to reach a high level of CR. The impact of this construct on structural and functional brain measures remains unclear.

Design/Methods 3D T1-weighted, diffusion tensor and resting-state functional MRI sequences were acquired from 77 HS (40 Men; mean age=36; range=22-65). For all subjects, global-Cognitive Reserve Index (CRI) and its subdomains (cognitive/social/physical) were assessed (higher scores reflect higher CR). Regional gray matter volume (GMv), white matter (WM) fractional anisotropy (FA) and resting-state functional connectivity (RS-FC) were estimated. Linear regression analyses were performed.

Results Higher global-CRI and its subdomains were positively associated with higher GMv of brain regions involved in motor functions, such as right (R) supplementary motor area, left (L) orbital middle frontal gyrus and L cerebellum. Higher cognitive-CRI was also correlated with higher GMv of L angular gyrus, while higher physical-CRI was correlated with higher GMv of L medial frontal gyrus and R middle cingulum. No correlations with WM FA were found. Higher global-CRI and its subdomains were associated with lower RS-FC of L postcentral gyrus in sensory-motor network (SMN). Moreover, higher global and social-CRI were correlated with lower RS-FC of R rolandic operculum in SMN and L postcentral gyrus in salience network (SN). Higher cognitive-CRI was correlated with lower RS-FC of R insula in SMN and L middle frontal gyrus in SN, whereas the remaining CRI scores (global/social/physical) were correlated with lower RS-FC of R cerebellum in the executive-control network.

Conclusions In young-adult HS, higher CRI modulates GM volumes of motor network and RS-FC of several motor and cognitive networks, whereas it is likely not to influence WM integrity.

Authors/Disclosures
PRESENTER	No disclosure on file
Gianna Carla Riccitelli (San Raffaele)	No disclosure on file
Carmen Vizzino	No disclosure on file
Paolo Preziosa (Ospedale San Raffaele)	Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers Squibb . Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi Genzyme. Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck.
Maria A. Rocca (Neuroimaging Research Unit)	Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen, Bristol Myers Squibb, Eli Lilly, Janssen, Roche. Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for AstraZaneca, Biogen, Bristol Myers Squibb, Bromatech, Celgene, Genzyme, Horizon Therapeutics Italy, Merck Serono SpA, Novartis, Roche, Sanofi and Teva. The institution of Maria Assunta Rocca has received research support from MS Society of Canada, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.
Massimo Filippi, MD, F�鶹��ýӳ�� (Ospedale San Raffaele, Neuroimaging Research Unit)	Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.

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