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Abstract Details

Prelimbic Cortex Inactivation Alters Prospective Reward Representation in Male Fischer 344 × Brown Norway F1 Hybrid Rats
Aging, Dementia, and Behavioral Neurology
P4 - Poster Session 4 (5:30 PM-6:30 PM)
10-008
Identify the role of prefrontal cortex (PFC) inhibition during distinct components (i.e., deliberation or outcome) of the decision-making process using optogenetic tools to dissect the contributions of the reciprocal projections between the prelimbic subregion of the PFC and the basolateral amygdala.
Intertemporal choice involves decisions among options that differ in both reward magnitude and delay to reward delivery. Executive functions such as integration of existing reward representations (prior experience) with valuation of the organism’s current wants and needs (incentive motivation) decision making, decline with age, and are supported by the PFC.
This study assesses temporal-based decision making with a delay discounting task in young (6 months) and aged (24 months) Fischer 344  brown Norway F1 hybrid rats. The delay discounting task also consists of four phases (deliberation, choice, outcome, and intertrial interval (ITI)). During the deliberation phase, rats are given the option between a small, immediate or large, delayed food reward, a choice is made, a rewarded outcome occurs and during the ITI the subject must wait until the following trial.
PFC inactivation during the ITI or small reward delivery had no effect on behavioral performance. PFC inactivation during the deliberation phase of the delay discounting task increased choice of large, delayed rewards in young rats only, whereas inactivation during the delayed outcomes increased choice of large, delayed rewards in aged rats only.
These data suggest distinct contributions of the PFC to executive function and decision making are altered with age. 
Authors/Disclosures
Chase Labiste
PRESENTER 		No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
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