Abstract Details

Title QUANTUM – Quantitative and Standardized Imaging in Daily Clinical Routine of MS Patients

Topic Multiple Sclerosis

Presentation(s) P2 - Poster Session 2 (8:00 AM-9:00 AM)

Poster/Presentation
Number 9-017

Objective

QUANTUM aims to evaluate if access to standardized quantification of MRI data and visualisation in reports, in addition to radiological findings provides additional benefit for neurologists working in day-to-day Multiple Sclerosis (MS) patient management.

Background

In MS clinical trials quantitative MRI analyses are carried out based on highly standardized protocols, comparable standards are yet to be implemented in clinical Routine.

Design/Methods

Approximately 9,000 MRI analyses will be performed in 300 centres in Germany. Standardized MRI data (3D T1 gradient-echo sequence and 2D/3D FLAIR) were analysed by means of a centralised automatic processing pipeline (Biometrica MS®, jung diagnostics GmbH). The analysis comprises volumetric quantification of brain volume, as well as T2 lesion load and number. Percentage brain volume change is computed (using optimized SIENA pipeline) when follow-up scans were available. The results were visualised and provided to the participating physicians as a report. The value and feasibility were evaluated using a questionnaire.

Results Since July 2016, 7046 quantitative MRI analyses were accomplished. Preliminary analysis of 4621 questionnaires (July 2016 – Sept 2019) revealed a good acceptance and usability of the QUANTUM reports. 72 .1% of neurologists reported a strong/very strong correlation between the quantitative MRI parameters in the QUANTUM reports and the clinical picture of patients. More than 75% of neurologists were able to use the report to better classify the patient's disease activity and they rate the additional benefit of the quantitative MRI parameters as high/very high in terms of achieving all four NEDA criteria. Full data analysis will be available for presentation at �鶹��ýӳ�� conference.

Conclusions

With QUANTUM standardization of MRI acquisition and MRI evaluation will be transferred into daily clinical practice. Quantification of lesion load and volume and visualisation of MRI abnormalities might be beneficial for the use of MRI data by neurologists in general and support the individual patient management.

Authors/Disclosures
Katrin Schuh (Novartis Pharma) PRESENTER	Katrin Schuh has received personal compensation for serving as an employee of Novartis Pharma GmbH.
	No disclosure on file
	No disclosure on file
Sven Schippling (University of Neurology)	No disclosure on file