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Abstract Details

Cognitive Impairment in Multiple Sclerosis: A Multiparametric Structural and Functional MRI Study
Multiple Sclerosis
P2 - Poster Session 2 (8:00 AM-9:00 AM)
9-003

To apply a multiparametric MRI approach to investigate the association between cognitive impairment (CI) in multiple sclerosis (MS) patients and specific patterns of structural and functional abnormalities.
CI affects a large proportion of MS patients, however its underlying substrates require further investigation.  
One-hundred healthy subjects (HC) and 297 MS patients underwent high-resolution 3D T1-weighted, diffusion tensor, dual-echo and resting state (RS) scans at 3.0 Tesla. Patients underwent an extensive neuropsychological evaluation. Grey matter (GM) atrophy, white matter (WM) microstructural abnormalities and RS functional connectivity (RS-FC) of the default mode network (DMN) were investigated using voxel-wise approaches. Factorial models were applied. 
Eighty-nine (30%) MS patients were classified as CI. Compared to HC, CP patients had significant GM atrophy of deep GM nuclei, in several regions of fronto-temporo-parietal and occipital lobes, cingulate cortex, and hippocampus, bilaterally. Additional widespread GM atrophy in supratentorial regions and the cerebellum were found in CI patients. Compared to CP, CI patients had GM atrophy in the thalamus, caudate nucleus, hippocampus, cerebellum, bilaterally and left supplementary motor area (SMA). Compared to HC, CP patients had decreased fractional anisotropy (FA) of supratentorial WM tracts, while CI patients had additional decreased FA of infratentorial WM tracts. Compared to HC, CP patients had reduced RS-FC in left SMA. CI patients had additional reduced RS-FC in the left posterior and middle cingulate cortex, the right inferior parietal lobule as well as increased RS-FC in the left inferior parietal lobule and right middle frontal gyrus. Finally, compared to CP, CI patients had reduced RS-FC in the left posterior cingulate cortex and right inferior parietal lobule. 
Structural abnormalities of critical CNS structures (deep GM nuclei, hippocampus and cerebellum) combined with functional maladaptive mechanisms contribute to explain CI in MS patients.
Authors/Disclosures
Carmen Vizzino
PRESENTER 		No disclosure on file
Gianna Carla Riccitelli (San Raffaele) No disclosure on file
Elisabetta Pagani Elisabetta Pagani has nothing to disclose.
Paola Valsasina Paola Valsasina has nothing to disclose.
Paolo Preziosa (Ospedale San Raffaele) Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bristol Myers Squibb . Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Sanofi Genzyme. Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Novartis. Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Roche. Mr. Preziosa has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Merck.
Massimo Filippi, MD, FÂ鶹´«Ã½Ó³»­ (Ospedale San Raffaele, Neuroimaging Research Unit) Dr. Filippi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Alexion, Almirall, Biogen, Merck, Novartis, Roche, Sanofi. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Alexion, Biogen, Bristol-Myers Squibb, Merck, Novartis, Roche, Sanofi, Sanofi-Aventis, Sanofi-Genzyme, Takeda. Dr. Filippi has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Bayer, Biogen, Celgene, Chiesi Italia SpA, Eli Lilly, Genzyme, Janssen, Merck-Serono, Neopharmed Gentili, Novartis, Novo Nordisk, Roche, Sanofi, Takeda, and TEVA. Dr. Filippi has received personal compensation in the range of $10,000-$49,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Springer Nature. The institution of Dr. Filippi has received research support from Biogen Idec, Merck-Serono, Novartis, Roche, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.
Maria A. Rocca (Neuroimaging Research Unit) Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Biogen, Bristol Myers Squibb, Eli Lilly, Janssen, Roche. Maria Assunta Rocca has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for AstraZaneca, Biogen, Bristol Myers Squibb, Bromatech, Celgene, Genzyme, Horizon Therapeutics Italy, Merck Serono SpA, Novartis, Roche, Sanofi and Teva. The institution of Maria Assunta Rocca has received research support from MS Society of Canada, the Italian Ministry of Health, the Italian Ministry of University and Research, and Fondazione Italiana Sclerosi Multipla.