Abstract Details

Title Natural History of Caregiver Burden After Deep Brain Stimulation for Parkinson Disease

Topic Movement Disorders

Presentation(s) P2 - Poster Session 2 (8:00 AM-9:00 AM)

Poster/Presentation
Number 3-004

Objective To determine the longitudinal change of caregiver burden (CB) after deep brain stimulation (DBS) of the bilateral subthalamic nucleus (STN) for Parkinson disease (PD)

Background Our group has previously demonstrated that CB after bilateral STN DBS for PD does not improve in the short term and may actually worsen instead. Data is lacking on long term, longitudinal changes of CB after DBS for individual patients and caregivers.

Design/Methods We analyzed data from 14 PD patients and their caregivers who had CB measured with the caregiver burden inventory (CBI) at baseline and at least twice after bilateral STN DBS. The follow up visits were around 1 year and 2 years after DBS. Two patients had a third visit around 2.5 years after DBS. Changes in CBI, 1) from baseline (BL) to follow-up visit 1 (Y1) and 2) from Y1 to follow-up visit 2 (Y2) were evaluated to explore the direction and magnitude of CBI change between these time points.

Results From BL to Y1, CBI scores generally increased--denoting worse caregiver burden (BL: 13.9 (SD: 11.3) vs. 20.7 (SD: 11.9); t=2.62, p=0.02). Between Y1 and Y2, there were no significant changes in mean CBI (20.7 (SD: 11.9) vs. 20.1 (SD: 10.4); t=0.32, p=0.76). When the two 1-year intervals were compared, there was a non-significant trend towards more CBI improvement in CBI scores between Y1 and Y2 in comparison to the interval between BL and Y1 assessments (t=2.12, p=0.053). CBI scores at Y2 following surgery were generally worse than pre-operative scores (t=2.23, p=0.044).

Conclusions CB worsens in the first year after DBS for PD and does not improve substantially in the second year. These findings may have implications on how providers, patients, and caregivers view the relative long-term benefits of DBS for PD.

Authors/Disclosures
Eric Jackowiak, MD (Medical College of Wisconsin) PRESENTER	No disclosure on file
Amelia L. Heston, MD (University of Michigan)	Dr. Heston has nothing to disclose.
	No disclosure on file
	No disclosure on file
	No disclosure on file
Kelvin L. Chou, MD, F�鶹��ýӳ�� (University of Michigan Health, Department of Neurology)	Dr. Chou has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Accordant. Dr. Chou has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Neurocrine. Dr. Chou has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Abbott. Dr. Chou has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Cerevance. Dr. Chou has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Advarra. The institution of Dr. Chou has received research support from NIH. The institution of Dr. Chou has received research support from Parkinson Study Group. The institution of Dr. Chou has received research support from Michael J Fox Foundation. The institution of Dr. Chou has received research support from Cerevance. Dr. Chou has received publishing royalties from a publication relating to health care. Dr. Chou has received publishing royalties from a publication relating to health care.
Vikas Kotagal, MD, F�鶹��ýӳ�� (University of Michigan)	Dr. Kotagal has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Movement Disorders Society. The institution of Dr. Kotagal has received research support from NIH. The institution of Dr. Kotagal has received research support from VA Healthcare System.

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