Abstract Details

Title Cerebral Small Vessel Disease Score and Atherosclerosis Burden: A Population-based Study in Rural Ecuador (The Atahualpa Project)

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) P2 - Poster Session 2 (8:00 AM-9:00 AM)

Poster/Presentation
Number 4-007

Objective

Cerebral small vessel disease (cSVD) and large artery atherosclerosis (LAA) are leading causes of stroke and cognitive impairment. These vascular phenotypes are thought to result from different pathogenetic mechanisms. However, relationships between single biomarkers of cSVD and LAA affecting isolated vascular beds have been reported. Here, we aimed to assess the association between cSVD score categories and LAA burden in a cohort of older adults living in a rural Ecuadorian village.

Background n/a

Design/Methods Utilizing a population-based design, individuals aged ≥60 years undergoing assessment of the cSVD score and LAA in the peripheral, extracranial carotid, and intracranial vascular beds (N=333) were included. Multivariate models were fitted to assess independent associations between the cSVD score and LAA burden.

Results The mean age of the population was 71.6 ± 8.4 years and 41% were male. The cSVD score was 0 points in 62% individuals, 1 point in 19%, 2 points in 13%, and 3-4 points in 7%. LAA involved the extracranial carotid bed in 43% individuals, the intracranial bed in 36%, and the peripheral bed in 20%. Only one vascular bed was involved in 33% individuals, two beds in 23%, and three beds in 7%. A fully-adjusted ordinal logistic regression model demonstrated that individuals who changed from 0 points in the cSVD score to 1, 2, and 3-4 points, had increased Odds (1.76 [95%C.I. 1.01–3.08], 2.61 [95%C.I. 1.30–5.26] and 16.7 [95%C.I. 6.34–44.2], respectively) of having more than one vascular bed involved. Multinomial logistic regression models showed associations between categories of cSVD score and LAA burden, but only when two or three vascular beds were involved.

Conclusions This study demonstrates robust associations between the cSVD score and LAA, which become evident at the upper end of the spectrum of cSVD score (3-4 points) and LAA burden (2-3 vascular beds involved).

Authors/Disclosures
Victor J. Del Brutto, MD PRESENTER	The institution of Dr. Del Brutto has received research support from Florida Health Department. The institution of Dr. Del Brutto has received research support from american heart association.
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Oscar H. Del Brutto, MD, F�鶹��ýӳ��	Dr. Del Brutto has received research support from Universidad Espiritu Santo - Ecuador.

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