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Abstract Details

Determinants of post lumbar puncture headache – the role of cerebrospinal fluid volume
General Neurology
P16 - Poster Session 16 (5:30 PM-6:30 PM)
6-004
Assessing factors that contribute to the development of post LP headache among patients with Parkinson's disease (PD) and healthy controls. 

Post LP headache is a relatively common side effect of dural puncture. Previous works found patient and operator related risk factors. We aimed to examine whether cerebrospinal fluid (CSF) volume as measured in pre-procedural brain MRI, is associated with the risk of developing post-LP headache.

A cohort of 117 participants; 58 PD patients and 59 healthy controls underwent an LP. Demographic and behavioral data was collected and CSF was assessed for content. High-resolution 3D magnetization-prepared rapid gradient echo (MP-RAGE) T1-weighted sequence scans were acquired from 89 of the participants using a 3T MR scanner. The T1-weighted images were segmented producing gray matter (GM), white matter (WM), and CSF probability maps to assess CSF volume.  
Thirteen participants (11.1%) experienced post LP headache. They were significantly younger (p=0.033) and had significantly lower CSF volumes (p=0.040) compared to the group that did not develop post LP headache.  Gender and body mass index did not differ between those who did and did not develop post LP headache.  

Low CSF volumes increase the risk for post-LP headache occurrence and should be taken into consideration when planning an LP.

Authors/Disclosures
Gadi Miron
PRESENTER 		No disclosure on file
Gadi Miron No disclosure on file
No disclosure on file
Tanya Gurevich, MD (Tel Aviv Medical Center) Dr. Gurevich has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Medison, Abbvie, Teva, Neuroderm . Dr. Gurevich has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Medison, Abbvie, Teva, Neuroderm, Truemed . Dr. Gurevich has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Medison, Acino Ukraine, Abbvie. The institution of Dr. Gurevich has received research support from Parkinson's Disease and Movement disorders society .
Yair Mina, MD (NIH) Dr. Mina has nothing to disclose.
Meir Kestenbaum, MD (Columbia University Medical Center) No disclosure on file
Jesse M. Cedarbaum, MD, FÂ鶹´«Ã½Ó³»­ (Coeruleus Clinical Sciences LLC) No disclosure on file
Nir Giladi, MD, FÂ鶹´«Ã½Ó³»­ (Tel-Aviv Medical Center) Dr. Giladi has received personal compensation in the range of $0-$499 for serving as a Consultant for Sionara. Dr. Giladi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for NeuroDerm. Dr. Giladi has received personal compensation in the range of $5,000-$9,999 for serving as a Consultant for Pharma2B. Dr. Giladi has stock in Vibrant. Dr. Giladi has stock in Lysosomal Therapeutics . The institution of Dr. Giladi has received research support from The Michael J Fox Foundation. The institution of Dr. Giladi has received research support from The National Parkinson Foundation. The institution of Dr. Giladi has received research support from The European Union . The institution of Dr. Giladi has received research support from The Israel Science Foundation. The institution of Dr. Giladi has received research support from Biogen . The institution of Dr. Giladi has received research support from Ionis. The institution of Dr. Giladi has received research support from Sieratzki Family Foundation . The institution of Dr. Giladi has received research support from The Aufzien Academic Center in Tel-Aviv University.
Anat Mirelman Anat Mirelman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Abbvie . Anat Mirelman has received personal compensation in the range of $500-$4,999 for serving as a Consultant for Bial. The institution of Anat Mirelman has received research support from Department of Defense. The institution of Anat Mirelman has received research support from MJFF. The institution of Anat Mirelman has received research support from JPND. The institution of Anat Mirelman has received research support from EU-Horizon 2020.
Avner Thaler, MD (Tel-Aviv Souraski Medical Center) The institution of Dr. Thaler has received personal compensation in the range of $500-$4,999 for serving as a Consultant for ABBVIE. The institution of Dr. Thaler has received research support from MJFF.