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Abstract Details

Personality Traits as Predictors of Pre-dementia Syndromes in Older Adults.
Aging, Dementia, and Behavioral Neurology
P15 - Poster Session 15 (12:00 PM-1:00 PM)
10-008
To examine patterns in personality traits as predictors of pre-dementia syndromes; Motoric Cognitive Risk syndrome (MCR) and Mild Cognitive Impairment (MCI).
Personality traits have been shown to be associated with risk of cognitive decline and dementia; however, the differential relationship between particular personality domains with MCR and MCI, including subtypes of MCI, has not been established. MCR builds on MCI operational definitions, substituting the cognitive impairment criterion with slow gait, and is associated with increased risk for both Alzheimer’s Disease and vascular dementia.
Of the 541 non-demented community-dwelling participants age 65+ at baseline, 22 (4%) met criteria for MCR, 58 (11%) for MCI, and 17 (3%) met criteria for both MCR and MCI, and were excluded from longitudinal analyses. Hence, we prospectively examined the association between personality domains and incident MCR and MCI in 444 non-demented participants. Personality traits were defined using the Big Five Inventory (BFI), a self-report measure designed to assess five aspects of personality: neuroticism, extraversion, conscientiousness, agreeableness, and openness. Cox proportional-hazard analysis was used to evaluate the risk of each pre-dementia syndrome based on baseline personality traits adjusted for age, sex, education and number of comorbidities.
Over a median follow-up of 2.2 years, 33 participants developed MCR and 65 developed MCI (39 non-amnestic MCI and 26 amnestic MCI). Openness was associated with reduced risk of developing incident MCR (adjusted Hazard Ratio (aHR): 0.94, 95% Confidence Interval (CI): 0.89-0.99) and neuroticism was associated with increased risk of incident non-amnestic MCI (aHR: 1.05 95%CI: 1.00-1.11). None of the personality traits were associated with MCI overall or amnestic MCI.
These findings provide evidence of a distinct relationship between patterns of personality and development of specific pre-dementia syndromes in aging.
Authors/Disclosures
Emmeline Ayers, MPH (Albert Einstein College of Medicine)
PRESENTER 		No disclosure on file
Joe Verghese, MD, FÂ鶹´«Ã½Ó³»­ (Stony Brook University) Dr. Verghese has received personal compensation in the range of $5,000-$9,999 for serving on a Scientific Advisory or Data Safety Monitoring board for MedRhythms Inc. The institution of Dr. Verghese has received research support from National Institutes of Health.