Abstract Details

Title How Much Propofol Treats Status Epilepticus ?

Topic Neuro Trauma, Critical Care, and Sports Neurology

Presentation(s) P14 - Poster Session 14 (8:00 AM-9:00 AM)

Poster/Presentation
Number 13-011

Objective The objective was to retrospectively review the management of status epilepticus at Tufts Medical Center. This dataset determines the minimal average dose/infusion rate of Propofol in patients at Tufts Medical Center in Boston MA that converted during EEG long term monitoring from active status epilepticus to an EEG that was devoid of organized seizure activity. Literature has not clearly delineated an actual minimal dose or infusion rate in studies of patients with status epilepticus. Identifying the minimal dose required has potential ramifications regarding the adequacy of timely intervention on such patients.

Background Timely and adequate treatment of status epilepticus has treatment implications within the complex health care system especially if patients are to be transported from various locations to another center. EEG may not always be readily available. Such a study would allow treating providers to have confidence that the minimal dose requirement for treating status epilepticus is met to potentially provide optimal outcomes.

Design/Methods With IRB approval, a retrospective database was created from 2015-present reviewing patients with the clinical diagnosis of status epilepticus. Multiple clinicopathologic variables were tabulated in a database along with minimal and maximal dose of infused medications and exactly when EEG converted to a pattern devoid of organized seizure activity during treatment.

Results

We studied 80 patients at Tufts Medical Center, Boston MA.

Treating status epilepticus involved complex decision making with multiple comorbidities and diagnostic variables and considerations that will be outlined in our tables and in the overall discussion.

The minimal propofol dose that was identified that terminated status epilepticus was approximately 40 mcg/kg/min

Conclusions Our retrospective review of treating status epilepticus at Tufts Medical Center identified that propofol at a dose of 40 mcg/kg/min was the minimally effective average dose at converting EEG LTM from status epilepticus to a pattern devoid of organized seizure activity.

Authors/Disclosures
Joel M. Oster, MD, F�鶹��ýӳ�� (Tufts University Department of Neurology) PRESENTER	The institution of Dr. Oster has received research support from Marinus Pharmaceuticals.
Kimberly A. Parkerson, MD, PhD	Dr. Parkerson has received personal compensation for serving as an employee of Stoke Therapeutics. Dr. Parkerson has stock in Stoke Therapeutics.
Joshua A. Kornbluth, MD (Tufts Medical Center)	Dr. Kornbluth has received personal compensation for serving as an employee of Tufts Medical Center. Dr. Kornbluth has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for ERI. Dr. Kornbluth has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for CRICO. The institution of Dr. Kornbluth has received research support from Vivonics, Inc.
Deborah M. Green-LaRoche, MD	The institution of Dr. Green-LaRoche has received personal compensation in the range of $10,000-$49,999 for serving as a Consultant for Boston Clinical Trials. Dr. Green-LaRoche has received publishing royalties from a publication relating to health care.
	No disclosure on file
Mohammad Tabaeizadeh Fesharaki, MD	Dr. Tabaeizadeh Fesharaki has nothing to disclose.
	No disclosure on file
	No disclosure on file
George Plummer, MD (University of Washington)	Dr. Plummer has nothing to disclose.

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