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Abstract Details

Cryptococcal meningitis complicated by cerebellar ischemic strokes and obstructive hydrocephalus in a patient with multiple sclerosis on fingolimod
Infectious Disease
P12 - Poster Session 12 (12:00 PM-1:00 PM)
13-005
To describe a unique presentation of Cryptococcal meningitis in a patient with multiple sclerosis treated with fingolimod which was complicated by granulomatous perivascular inflammation resulting in bilateral cerebellar strokes and obstructive hydrocephalus.
It is recognized that immunosuppression with fingolimod in patients with multiple sclerosis does cause a predisposition for opportunistic infections including Cryptococcal meningitis. There have been reported cases of ischemic strokes associated with Cryptococcal meningitis and of leptomeningeal inflammation leading to obstructive hydrocephalus. This is a case of biopsy-proven Cryptococcal meningitis with vascular involvement of suppurative and granulomatous inflammation and complicated by bilateral cerebellar ischemic strokes and obstructive hydrocephalus.
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Cryptococcal meningitis complicated by ischemic stroke appears to be a rarely reported phenomenon. This case with extensive cerebellar involvement and vascular involvement of inflammation demonstrated on biopsy is not previously described in the literature.
Authors/Disclosures
Kelsey A. Coleman, DO (Hershey Medical Center)
PRESENTER 		Dr. Coleman has nothing to disclose.
Joseph E. Malone, MD (West Virginia University Rockefeller Neuroscience Institute) Dr. Malone has nothing to disclose.
Grant W. Zeigler, DO (Penn State Hershey Medical Center) Dr. Zeigler has nothing to disclose.
Tiffany L. Fisher, MD, PhD (UTHSc) Dr. Fisher has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Neurelis, Inc.