Multiple sclerosis (MS) commonly affects young women of childbearing age and they frequently face issues related to become pregnant. There are some myths and doubts about pregnancy, newborn and progression of MS, so many patients are afraid to become pregnant

To study the pregnancy and obstetrical outcomes of RRMS patients in a prospective cohort of a MS Center.

A five year observational study was done. We followed-up prospectively MS patients, who wanted to become pregnant, the evolution of pregnancies and twelve months post-partum. We collected information about concomitant diseases, contraceptives methods, artificial reproductive techniques (ART),disease-modifying therapies (DMTs), anaesthesia, kind of delivery and outcomes of the newborns. We compare these data with data of healthy women.

66 pregnant women with 85 pregnancies were followed during five years. The mean age was 35 years (25-43), mean BMI 22.41. 67.8% were treated with DMTs before pregnancy, 15.29% of them with second-line treatment. 20.48% were smokers. 15.29% received ART. 11.11% of patients suffered gestational diabetes. Mean duration of pregnancy was 38.91±2.10 weeks. C-sections were performed in 23.37% of them. 13.56% of patients didn’t receive epidural anaesthesia during the vaginal birth. All pregnancies resulted in live births, with no complications. Only 2.60% of malformations in newborns were reported. The mean birthweight was 3198.12g, the birthheight was 49.75cm and the cephalic perimeter 34.91cm. 56.58% gave exclusive breastfeeding. 18.84% of patients had new lesions in brain MRI performed at two month after delivery. When we compare these data with the national and obstetrical Spanish register there were no significant differences.

MS patients have very similar pregnancy and obstetrical outcomes as the healthy women population. Newborns from MS patients have similar outcomes as the newborns of the Spanish healthy population. In conclusion there are no obstetrical or neurological reasons to avoid pregnancy in MS patients.