Â鶹´«Ã½Ó³»­

Â鶹´«Ã½Ó³»­

Explore the latest content from across our publications
Join The Â鶹´«Ã½Ó³»­

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Precision-Medicine in Post-Concussion Syndrome by Relating Subject Specific Structural-Functional Connectomes and Neuropsychological Measures
Neuro Trauma, Critical Care, and Sports Neurology
P10 - Poster Session 10 (5:30 PM-6:30 PM)
5-011

In order to better capture the heterogeneity of patients with Post-Concussion Syndrome (PCS), we hypothesized that differences in structural-functional connectomes could underlie the different clinical patterns of impairment or symptom in patients with PCS.

PCS is a heterogenous condition that includes cognitive impairments, mood disorders and constitutional symptoms including visual disturbances. Currently there are no diagnostics biomarkers for PCS and the heterogeneity of symptoms makes targeted therapies difficult to deliver.
We created subject specific structural and functional connectomes based on Diffusion Weighted Imaging (DWI) and Resting State Functional Magnetic Resonance Imaging (rs-fMRI), respectively. We identified sets of gray matter pairs, that showed different coactivation patterns or reduced integrity in white matter tracts that connected the two regions, in PCS patients (N=82) in comparison to controls (N=17). Based on these identified regions, we subtyped PCS patients into severe and mild groups, using a gaussian mixture model.
The PCS group who had lower white matter integrity between Right Cingulate and Pericalcarine scored lower in Stroop Colour-Word Naming Task (p<0.05). Similarly, PCS patients that reported higher number of vision symptoms exhibited greater co-activation of right-left lingual (p<0.05).
Our results revealed differences in structural-functional connectome between PCS patients with cognitive deficits and more visual symptoms in comparison to PCS patients who displayed similar neuroimaging and cognitive profiles as healthy controls. The structural-functional connectome changes may represent the neural substrate to explain the heterogeneity of PCS.
Authors/Disclosures

PRESENTER 		No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
David J. Mikulis, MD (Toronto Hosp Western Div) Dr. Mikulis has received personal compensation in the range of $10,000-$49,999 for serving as an Expert Witness for Neinstein Personal Injury Lawyers. Dr. Mikulis has received stock or an ownership interest from Thornhill Medical, Inc.. Dr. Mikulis has received intellectual property interests from a discovery or technology relating to health care.
No disclosure on file
Apameh Tarazi, MD (Toronto Western Hospital) No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
Carmela Tartaglia, MD (Toronto Western Hospital, University of Toronto) Dr. Tartaglia has received personal compensation in the range of $0-$499 for serving on a Scientific Advisory or Data Safety Monitoring board for Roche. The institution of Dr. Tartaglia has received research support from NIH. The institution of Dr. Tartaglia has received research support from University of Toronto.