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Abstract Details

Relationship of Self-Reported Home Seizure Frequency to Seizure Occurrence and Time to Seizure Onset in Children Undergoing Presurgical Workup in the Long Term Monitoring Unit
Epilepsy
P05 - (-)
095
BACKGROUND: Data on seizure-occurrence in children undergoing presurgical LTM is lacking. Children undergoing monitoring for epilepsy surgery require longer duration of expensive monitoring and can increase the risk for prolonged seizures.
DESIGN/METHODS: We retrospectively collected data on ninety-five patients admitted to LTM unit. Home seizure-frequency was defined as low (up-to 1/month), medium (up-to 1/week) and high (>1/week). Relationship between seizure-occurrence and home seizure-frequency was analyzed by logistic regression, and between time-to-seizure-onset and home seizure-frequency by Cox Proportional Hazards and Kaplan-Meier survival models.
RESULTS: Twenty-two patients were in low, eighteen in medium and fifty-five in high-frequency group. Eighty-eight patients had at-least one seizure during monitoring. Odds of first-seizure increased by 15.88 in high vs. low-frequency group (p=0.01), and by 10.4 in medium-high vs. low-frequency group (p=0.0076). Hazard rate for first-seizure in high-frequency group was 2.17 times higher than low-frequency group (p=0.006), and 2.06 times higher for high-medium frequency group than low-frequency group (p=0.008). Time-to-onset of first-seizure was lesser in high-frequency group than low-frequency group (p=0.0004); and in medium-high frequency group than low-frequency group (p=0.0007). Odds of second-seizure increased by 37.38 in high vs. low-frequency group (p=0.001), and by 11.77 in medium vs. low-frequency group (p=0.027). Home seizure-frequency did not significantly predict time-to-onset of second-seizure in any three categories. Odds of >3 seizures increased by 3.6 in high vs. low-frequency group (p=0.03), by 5.7 in medium-high vs. low-frequency group (p=0.0008). Other factors (age/gender/seizure-localization/prolonged-seizure/neuro-exam) were not significant predictors for odds/time-to-onset/hazard-rate of first-seizure (p>0.05).
CONCLUSIONS: Of all factors examined only home-seizure frequency correlated with occurrence and time-to-onset of seizures during monitoring. Low-frequency patients are less likely to have multiple seizures which can affect successful completion of pre-surgical monitoring.
Authors/Disclosures

PRESENTER 		No disclosure on file
Sanjeev V. Kothare, MD, FÂ鶹´«Ã½Ó³»­ (Cohen Children's Hospital, Northwell Health) Dr. Kothare has nothing to disclose.
Masanori Takeoka, MD (Children'S Hospital Boston) No disclosure on file
Tobias Loddenkemper, MD, FÂ鶹´«Ã½Ó³»­ No disclosure on file
No disclosure on file
No disclosure on file