Abstract Details

Title Early Optical Detection of Cerebral Edema In-Vivo

Topic Critical Care/Emergency Neurology/Trauma

Presentation(s) P03 - (-)

Poster/Presentation
Number 147

Objective

Background BACKGROUND: Cerebral edema in traumatic brain injury is associated with significant mortality and morbidity. The current clinical standard to detect cerebral edema is intracranial pressure (ICP) measurements. A direct, minimally invasive method to interrogate water movement would be a valuable tool in neurocritical care.

Design/Methods DESIGN/METHODS: A dual-fiberoptic probe was connected to a laser diode generating near-infrared light (850nm wavelength). The water intoxication model was used to induce cytotoxic cerebral edema. The fiberoptic probe was inserted into the brain of wild-type mice stereotactically. An ICP monitor was inserted contralaterally. A steady optical baseline was obtained before injecting water (30% body weight, i.p.) in the experimental animals and normal saline in control animals."Optical trigger" was calculated as two standard deviations reduction in optical signal. (Figure 1A,B & C - Not submitted in abstract).

Results RESULTS: The optical trigger was detected 31 minutes before the ICP measurements changed from baseline pressure of 3-6mm Hg to a pathological ICP of 20mm Hg (n=3,p<0.001). Significant change in optical signal was also detected well before ICP rises to 10 and 15mm Hg. The saline injected controls showed a steady optical baseline.

Conclusions CONCLUSIONS: We have validated a novel near-infrared optical probe to detect the early phase of cerebral edema. This type of detector could be clinically applicable to patients with various types of brain injury.

Authors/Disclosures
Kiran F. Rajneesh, MD, F�鶹��ýӳ�� PRESENTER	An immediate family member of Dr. Rajneesh has stock in Crossliner.
Devin K. Binder	No disclosure on file
Astrid Scheschonka	No disclosure on file

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