Abstract Details

Title Impact of Community �鶹��ýӳ�� Levels on Cognitive Outcomes Post-COVID-19

Topic Global Health and Neuroepidemiology

Presentation(s) P1 - Poster Session 1 (8:00 AM-9:00 AM)

Poster/Presentation
Number 6-011

Objective To evaluate the impact of community education levels on cognitive outcomes post-COVID-19.

Background Brain fog post-COVID-19 is common, yet community factors that impact cognitive outcome are not well described.

Design/Methods We conducted a prospective, observational study of adult COVID-19 patients with no pre-COVID history of cognitive impairment. Publicly available community data were matched to patient-level data by zip code including regional rates of school absenteeism, rates of high school graduation, and average math and English standardized test scores for grades 3-8. Cognitive testing (Telephone Montreal Cognitive Assessment [tMoCA]) was performed at 6-, 12- and 36-month post-COVID. Associations of abnormal tMoCA scores (≤18), and improvement in tMoCA (≥1 point between 6-36 months) with community and patient-level education variables were assessed using logistic regression analyses.

Results tMoCA data were available for 219 patients (N=137 at 6-months, N=109 at 12-months, N=62 at 36-months, and N=81 had repeated measures of tMOCA between 6-36 months). The median age was 63 years (IQR 51-72), 22% of the cohort did not complete high school, and 76% had ≥13 years of education. In univariate models, patient-level education≥college, higher community rates of on-time high school graduation, higher grade-school math and English test scores, and lower rates of school absenteeism and high-school drop-out were associated with significantly better odds of normal tMOCA scores (all P<0.05). In backwards, stepwise, multivariable logistic regression models, higher community grade school English tests scores were associated with normal tMOCA scores at 6-months (aOR 0.90, 95%CI 0.83-0.97, P=0.004), and patient-level education≥college was associated with normal tMOCA scores at 12-months (aOR 0.33, 95%CI 0.12-0.95, P=0.040). In patients with repeated tMOCA assessments, only patient-level education≥college was associated with improvements in tMOCA between 6-36 months (OR 2.72, 95% CI 1.08-6.86, P=0.034).

Conclusions Higher community and patient-level education status was associated with better cognitive outcomes post-COVID.

Authors/Disclosures
Cebastian P. Blot PRESENTER	Mr. Blot has nothing to disclose.
Pierce Brody	Mr. Brody has nothing to disclose.
Salma Hammam	Ms. Hammam has nothing to disclose.
Daria Vasilchenko	Ms. Vasilchenko has nothing to disclose.
Zariya Alvarez	Miss Alvarez has nothing to disclose.
Jennifer A. Frontera, MD (NYU Langone Health)	Dr. Frontera has received personal compensation in the range of $500-$4,999 for serving as a Consultant for FirstKindMedical. Dr. Frontera has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for Physician �鶹��ýӳ�� Resource. The institution of Dr. Frontera has received research support from NIH. The institution of Dr. Frontera has received research support from Alexion. Dr. Frontera has received publishing royalties from a publication relating to health care.