We report a 27-year-old single woman known to have had prolactinoma for 7 years and migraine without aura improved with over-the-counter oral analgesia. 3 days prior to current presentation, she was seen in gynecology clinic with irregular periods and high prolactin, so cabergoline was prescribed with the dose of 0.5 mg orally once a week. She suddenly developed thunderclap headache and 1st two episodes of seizure preceded by chest pain, sweating, dizziness, and non-bloody vomiting on the third day of exposure to cabergoline. Upon ER arrival, the patient was conscious, awake, alert, oriented, and hemodynamically and clinically stable. Neurologic examination was normal. CT brain demonstrated left frontal intra-parenchymal bleeding up on patient presentation. The first cerebral DSA revealed segmental constriction and dilatation of multiple median and small sized arteries. Although (DSA) revealed medium arteries irregularities, follow up DSA finding after cabergoline discontinuation showed complete remission of the stenosis. Moreover, she recovered without any neurological symptom other than mild headache controlled by amitriptyline.