Abstract Details

Title P 300 Latency in Patients With Parkinson’s Disease Without Dementia and its Association with Motor Symptoms and Cognitive Performance

Topic Movement Disorders

Presentation(s) Movement Disorders Posters (7:00 AM-5:00 PM)

Poster/Presentation
Number 078

Objective The aim of this study was to measure P300 wave latencies in Parkinson’s disease (PD) patients without dementia (MoCA score>21/30) and to assess its association with motor features of PD and performance in cognitive tests (MOCA & FAB).

Background PD is a neurodegenerative disorder with a plethora of symptoms attributable to both dopaminergic and non-dopaminergic neurotransmitter dysfunction, involving multiple subcortical and cortical networks. Sensitive tests for early detection of cognitive dysfunction in PD are currently unavailable. A late evoked potential, P300, has a potential utility in identifying this cognitive dysfunction.

Design/Methods A total of 30 patients with confirmed diagnosis of PD (by UK Brain Bank criteria) were selected for the study. Among them 9 were excluded because of a MoCA score < 21/30. In the rest of the patients UPDRS score, MoCA & FAB score and P 300 latencies using an auditory stimulus with odd ball paradigm were measured

Results All patients had prolonged P300 latencies, with the mean being 328.7 ms (SD=9.8). The mean age of patients in the study was 61.19 years (SD=6.75), median duration of illness was 60 months (IQR: 36-90 months), mean UPDRS score was 71.57 (SD=6.9), mean MoCA score 26.1 (SD=0.9), mean FAB score 13.05 (SD=1.5). On analysis P300 latency showed statistically significant positive correlation with total UPDRS score (r=.68, p<0.01), presence of dyskinesia (r=0.6, p<0.01), gait freezing (r=.45, p-0.04) and postural abnormalities.

Conclusions Our study identified P 300 latency prolongation in all patients with idiopathic PD, even in the absence of clinical features, suggestive of sub-clinical cognitive impairment. The latency prolongation correlated with total UPDRS score suggesting an association with the disease severity but not with the motor sub-component. Clinical features such as dyskinesia, gait freezing and postural abnormalities showed a positive correlation with prolonged P 300 latencies suggesting the role of non-dopaminergic systems towards the contribution of these features

Authors/Disclosures
Shrivarthan R PRESENTER	Mr. R has nothing to disclose.
Manickavasagam Janarthanam, DM (Madras Medical College)	No disclosure on file
Lakshmi N. Ranganathan, MD, PhD, F�鶹��ýӳ��	Dr. Ranganathan has nothing to disclose.

�鶹��ýӳ��

�鶹��ýӳ��