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Abstract Details

Sleep And Autonomic Dysfunction In Idiopathic Sporodic Cerebellar Ataxia
Movement Disorders
Movement Disorders Posters (7:00 AM-5:00 PM)
026
Assessment of  RBD and autonomic dysfunction in idiopathic, sporadic adult-onset progressive ataxia.
 Concomitant autonomic dysfunction with RBD in idiopathic cerebellar ataxia may herald its phenoconversion into MSA-C. Assessment of these non-motor symptoms may increase the sensitivity of preclinical identification of MSA-C subgroups in large idiopathic, sporadic cerebellar ataxia cohort.
Demographic and clinical data of 42 patients of idiopathic sporadic cerebellar ataxia, with disease onset after 25 years was collected. Questionnarie based RBDSQ, assessment of severity of ataxia using ICARS scale, autonomic function test and polysomnography were done.

We enrolled 42 patients between December 2018 to March 2020.  The mean age of onset and duration of disease was 49.9 years and 4.12 years respectively and majority were male (72.5%).  59.5% had  score ≥5 on RBDSQ with mean of 8.1. Mean of ICARS score was 42.4± 16.5. 40.4% had symptoms of autonomic dysfunction with prominent urinary symptoms. In 25 (59%) patients, a diagnosis of possible or probable MSA was made. 40.4% participants were categorized as idiopathic late onset cerebellar ataxia (ILOCA). Duration of symptoms among probable or possible MSA-C was 3.6 ± 2.4 vs 4.7 ± 3.7 years in ILOCA groups, with p-value of 0.24. Greater severity of cerebellar symptoms (p value 0.0006), higher score in RBDSQ questionnaire (p value-0.008) and dysautonomia was observed in probable or possible MSA-C patient. 18 patient who undergone overnight polysomnography, none had evidence of RBD while all patient had some degree of sleep breathing disorder. No difference was observed in ILOCA patient with RBD or without RBD.
We confirmed significant prevalence of RBD based on RBDSQ and dysautonomia in MSA-C subgroup with shorter duration of disease and more disabled cerebellar symptoms. No difference was found in ILOCA patient with RBD or without RBD. Higher prevalence of sleep breathing disorder was observed among idiopathic sporadic cerebellar ataxia.
Authors/Disclosures
Meena Lanjiwar, DM (Kakash Hospital Neuro.)
PRESENTER 		Dr. Lanjiwar has nothing to disclose.
Achal K. Srivastava, MD, FÂ鶹´«Ã½Ó³»­ (AIIMS) Dr. Srivastava has nothing to disclose.