Abstract Details Title Bupropion Overdose Induced Reversible Burst Suppression and Myoclonic Seizures Topic Epilepsy/Clinical Neurophysiology (EEG) Presentation(s) Epilepsy/Clinical Neurophysiology (EEG) Posters (7:00 AM-5:00 PM) Poster/Presentation Number 092 Objective NA Background Bupropion is a selective re-uptake inhibitor of dopamine and noradrenalin, which is widely used for the management of major depression and smoking cessation. We are reporting a case of a 23-year old female who developed new onset myoclonic seizures and burst suppression EEG pattern after intentional bupropion overdose and had a complete recovery after administration of intravenous levetiracetam and lorazepam. Design/Methods NA Results Our patient was prescribed bupropion for depression and had an intentional overdose. She was found to have witnessed convulsion with cyanotic lips. Intravenous midazolam was given by EMS. Patient had no cardiac arrest but needed vasopressors due to low blood pressure. On arrival, patient had a Ceribell EEG done, which showed diffuse suppression. Later during conventional EEG recording, patient had severe burst suppression and very frequent myoclonic seizures. Patient was given intravenous levetiracetam and lorazepam, which showed significant EEG improvement. Within 3 hours of antiseizure medication administration, there was complete resolution of the burst suppression pattern. EEG showed more continuous low background activity and no further seizures. Later, she was found to have normal MRI brain or no evidence of hypoxic ischemic encephalopathy. On her 7th hospital day, she was extubated and the following day, she was alert, oriented, and denied suicidal ideation. Her levetiracetam was discontinued, as an EEG showed no seizure activity. The patient was discharged on her 10th hospital day. Conclusions Usually, burst suppression is consistent with a severe diffuse disturbance of cerebral function and typically indicates a poor prognosis. However, the burst suppression pattern associated with bupropion overdose is completely reversible, and treatment with anti-seizure medication may result in faster recovery. Authors/Disclosures Monica J. Goodman PRESENTER Monica Goodman has nothing to disclose.