Â鶹´«Ã½Ó³»­

Â鶹´«Ã½Ó³»­

Explore the latest content from across our publications
Join The Â鶹´«Ã½Ó³»­

Log In

Forgot Password?
Create New Account

Loading... please wait

Abstract Details

Seizures and Kidney Transplantation: description of a 10-year cohort
Epilepsy/Clinical Neurophysiology (EEG)
Epilepsy/Clinical Neurophysiology (EEG) Posters (7:00 AM-5:00 PM)
091
To determine prevalence of epileptic events in kidney transplant patients and to describe related variables.
Seizures in kidney transplant patients represent 7-10% of neurological complications. Usually, the cause is multifactorial (infectious, pharmacological, metabolic).
Descriptive observational retrospective study. Medical records of adult patients who presented seizures after renal transplantation between 2009 and 2020 were reviewed. Age, type of seizure, time since transplant, medication, laboratory and images were collected.

Among 632 renal transplant patients, 60 (9%) had seizures. Female sex 46,7%; mean age 55 years (SD 17,7).

Seventeen patients (27%) had seizure history, 10 of them acute symptomatic seizures and 7 had previous epilepsy. We observed 11 generalized seizures, 38 focal and 2 of uncertain onset. Nine patients presented status epilepticus (7 non-convulsive and 2 convulsive status epilepticus). 61% were interpreted as acute symptomatic seizures, 8% remote ones, the rest being without a definitive cause. Median since transplant 278,5 days (IQR 39,5-1184,75). At the time of the ES, 96% received steroids and 50% calcineurin inhibitors. Lab test: mean hematocrit 30,2% (SD 5,8), sodium 135,9 mEq/l (SD 7,9), uremia 103,7 mg/dl (SD 54,9), tacrolimus level 10,5 ng/ml (SD 7,3) and glycemia 130 mg/dl (SD 59). Thirty-five patients received antibiotic therapy, with a risk of lowering the seizure threshold in 29 of them (being the most common: meropenem). 20% presented concomitant graft rejection. Imaging findings were abnormal in 44 cases. During the hospitalization of the neurological event we found 25 deaths (41%).
Throughout a 10-year follow-up in patients with kidney transplant, we found a seizure prevalence of 9%, consistent with the literature. These patients presented systemic and neurological triggers: anemia, hyponatremia, and elevated urea. Pathological neuroimaging was common, and seizures were associated with high in-hospital mortality.
Authors/Disclosures

PRESENTER 		No disclosure on file
Franco E. Appiani, MD (ACE Alzheimer Cente - Instituto Catalán de Neurociencias Aplicadas) Dr. Appiani has nothing to disclose.
Carla F. Bolano Diaz, MD (John Walton Muscular Dystrophy Research Centre) Dr. Bolano Diaz has nothing to disclose.
Guido D. Vazquez II, PhD (Neurociencias Favaloro) Dr. Vazquez has nothing to disclose.
Carlos Santiago Claverie, MD (Favaloro Foundation) No disclosure on file
Veronica Campanille, MD No disclosure on file
No disclosure on file
Alfredo Thomson, MD (Favaloro Foundation) Dr. Thomson has nothing to disclose.