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Abstract Details

Characterization of Memory Outcome Following Temporal Lobe Resection in Children with Epilepsy
Epilepsy/Clinical Neurophysiology (EEG)
Epilepsy/Clinical Neurophysiology (EEG) Posters (7:00 AM-5:00 PM)
102

To characterize memory outcome in children with pharmacoresistant epilepsy following temporal lobe resection (TLR).
Studies examining memory outcome after pediatric epilepsy surgery report varying results; some report overall decline, and others no change or improvement. Most studies are based on group data and fail to account for factors that may impact test-retest change in the absence of surgical effects. Reliable change indices (RCIs) control for test reliability, practice effects, and measurement error. RCIs developed for children with epilepsy were used to examine base rates of postoperative memory change and identify factors associated with memory decline.

105 children completed the Children’s Memory Scale (CMS) before and ~8 months after TLR. Children were 6-16 years old, underwent TLR, and had no prior neurosurgical resection. Change scores on each CMS index were categorized as declined, unchanged, or improved using RCIs (80% confidence interval). Base rates of change were examined, and chi-square, fisher’s exact, and t-tests were used to identify factors associated with memory decline.

Memory improvement was observed in 5-14% of patients. Decline was observed in 25% and 34% of patients on the visual immediate and delayed indices, and 33% and 29% of patients on the verbal immediate and delayed indices, respectively. Factors associated with decline in verbal memory included dominant resection (P=0.02), older age at seizure onset (P=0.04), and poor seizure outcome (P=0.02). Higher preoperative scores were consistently associated with postoperative decline (all P<0.02). 

While the majority of children have good memory outcomes following TLR, there is a subset of children (25-34%) who demonstrate declines on memory measures. Several variables associated with memory decline were identified and may be used to develop models to predict memory outcome following pediatric epilepsy surgery. 
Authors/Disclosures
Navkiranjot Kaur
PRESENTER 		Ms. Kaur has nothing to disclose.
No disclosure on file
No disclosure on file
No disclosure on file
Deepak K. Lachhwani, MD, FÂ鶹´«Ã½Ó³»­ (Cleveland Clinic Foundation/) The institution of Dr. Lachhwani has received research support from ICON Clinical Research LLC.
No disclosure on file
Tara T. Lineweaver, MD Dr. Lineweaver has nothing to disclose.
Amy Nowacki Amy Nowacki has nothing to disclose.
Robyn Busch Robyn Busch has received personal compensation in the range of $500-$4,999 for serving as an Editor, Associate Editor, or Editorial Advisory Board Member for Elsevier Inc.. Robyn Busch has received research support from National Institutes of Health. Robyn Busch has received research support from American Epilepsy Society. Robyn Busch has received research support from Cleveland Clinic. Robyn Busch has received research support from Ohio Department of Higher Â鶹´«Ã½Ó³»­. Robyn Busch has received intellectual property interests from a discovery or technology relating to health care.