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Abstract Details

Hippocampal Atrophy and Quantitative EEG Markers in Mild Cognitive Impairment in Temporal Lobe Epilepsy versus Extra-Temporal Lobe Epilepsy
Epilepsy/Clinical Neurophysiology (EEG)
Epilepsy/Clinical Neurophysiology (EEG) Posters (7:00 AM-5:00 PM)
138
This study aimed to explore Cognitive impairment (CI) and to determine the potential clinical, radiological, and quantitative electroencephalography (QEEG) markers for CI in temporal lobe epilepsy (TLE) patients versus extra-TLE (ETLE).

Cognitive impairment in temporal lobe epilepsy (TLE) is widely acknowledged as one of the most well-known comorbidity of TLE. 
Forty-five patients with TLE and forty-five patients with ETLE were recruited for an administered digit span test (DSp), verbal fluency test (VFT), mini-mental state examination (MMSE), digital symbol test (DSy), and Montreal cognitive assessment (MoCA). Also, they were subjected to an MRI assessment for hippocampal atrophy (HA), and a QEEG assessment for EEG markers [median frequency (MF), peak frequency (PF), and the alpha-to-theta ratio (ATR)].
The study was conducted on 90 adult epileptic patients (50 males and 40 females; mean age 24.5 ± 5.63; mean onset of disease 15.68 ± 9.21). Patients with ETLE showed non-significant higher epilepsy durations and a higher frequency of seizures. TLE patients showed a more statistically significant family history of epilepsy (37.7%), more history of febrile convulsions (13.3%), higher HA (17.8%), lower cognitive scales – especially MMSE and MoCA, lower DSy, VFT, and backward memory of DSp. Also, TLE patients had a strong negative correlation with EEG biomarkers: MF, PF, and ATR (r= -0.68, P<0.005 & r= -0.64, P<0.005 and r= -0.66, P<0.005 respectively).
The CI in patients with TLE was correlated with HA and QEEG abnormalities, especially PF, MF, and ATR that could be used alone for the identification of early CI.
Authors/Disclosures
Mohammed A. ElSherif, MD, PhD, FÂ鶹´«Ã½Ó³»­ (Mansoura University)
PRESENTER 		Dr. ElSherif has nothing to disclose.
No disclosure on file