For patients with medically refractory temporal lobe epilepsy, early surgical resection has been proven to be superior to prolonged medical therapy. However, for patients with seizures originating from extratemporal areas such as the frontal lobe who have multiple seizure foci, evidence supporting the benefit for surgical resection is less clear. RNS offers an alternative therapeutic option, however there is currently little literature regarding outcomes for this population after RNS placement.

Single institution retrospective review of five patients with multifocal epilepsy involving the frontal lobe who received RNS. Patient reported seizure frequency and severity prior to and following RNS placement were compared.

Our case series suggests that RNS may be especially beneficial to the frontal lobe epilepsy population. A larger study to address outcomes for patients with frontal lobe epilepsy who receive RNS is required.