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Abstract Details

Association of Five-Day Hemoglobin and Hematocrit Values on Functional Outcomes in Patients with Mechanical Thrombectomy
Cerebrovascular Disease and Interventional Neurology
Cerebrovascular Disease and Interventional Neurology Posters (7:00 AM-5:00 PM)
195
We aim to investigate the association of hemoglobin and hematocrit (HCT) values and their variability with functional outcomes in patients who undergo mechanical thrombectomy (MT).
Lower hemoglobin and HCT values are associated with worse outcomes in patients with an acute ischemic stroke.
We performed a retrospective chart review of patients who underwent MT for anterior circulation large vessel occlusion at a comprehensive stroke center from 7/2014 to 5/2020. Hemoglobin (g/dL) and HCT (%) values were collected for the first five days of admission after MT and were considered as continuous variables. A binary logistic regression analysis was performed, controlling for age, gender, pre-treatment-NIHSS, TICI score ≥2b, onset to recanalization time, and administration of intravenous-alteplase (IV-rtPA), with the hemoglobin and HCT values as the predictors. The primary outcome was a bad functional outcome at 3-months (mRS of ≥5). 
176 patients met our inclusion criteria. 73 (41.46%) patients had a bad outcome. The lower mean hemoglobin (11.58±1.93 vs.11.97±1.86; OR, 0.82; 95% CI, 0.67-0.99; P 0.048), a higher hemoglobin variance (1.75±2.04 vs.1.03±0.93; OR, 1.54; 95% CI, 1.15-2.06; P 0.004) and a higher difference between peak and trough hemoglobin (2.66±1.49 vs.2.1±1.02; OR, 1.54; 95% CI, 1.15-2.06; P 0.004) was significantly associated with a bad outcome. In our cohort, a higher HCT variance (15.64±17.92 vs9.29±8.06; OR, 1.05; 95% CI, 1.02-1.08; P 0.007) and a higher difference between peak and through HCT (8.05±4.42 vs.6.28±3.05; OR, 1.16; 95% CI, 1.05-1.27; P 0.003) was significantly associated with a bad outcome. A lower mean HCT (35.08±5.75 vs.36.16±5.18; OR, 0.94; 95% CI, 0.88-1.01; P 0.074) was not associated with a bad outcome.
Our study demonstrates that lower mean hemoglobin and variability in hemoglobin and HCT parameters over the first five days of MT is associated with a bad outcome.
Authors/Disclosures
Taha Nisar, MD (Rutgers New Jersey Medical School)
PRESENTER 		Dr. Nisar has nothing to disclose.
Sara Shapouran, MD (Montefiore) Dr. Shapouran has nothing to disclose.
Osama M. Abu-hadid, MD Dr. Abu-hadid has nothing to disclose.
Shaul Shaulov, MD (Department of Neurology at Rutgers NJMS) Dr. Shaulov has nothing to disclose.
Toluwalase O. Tofade, MBBS (Medstar) Dr. Tofade has nothing to disclose.