Abstract Details

Title History of Stroke Confers High Mortality among Middle Aged Patients with COVID-19 Infection: Results from the Louisville COVID-19 Study

Topic Cerebrovascular Disease and Interventional Neurology

Presentation(s) Cerebrovascular Disease and Interventional Neurology Posters (7:00 AM-5:00 PM)

Poster/Presentation
Number 018

Objective The objective of this study was to evaluate mortality patterns among patients with history of stroke/TIA who were enrolled in a retrospective study of patients hospitalized with COVID-19 at eight different hospitals in the city of Louisville, Kentucky.

Background The global coronavirus disease (COVID-19) pandemic has been associated with increased Mortality. It is essential to identify comorbidities associated with this increased risk.

Design/Methods Records from the Louisville COVID-19 Study database met inclusion if they were hospitalized between the dates March 15 to June 20, 2020. Groups with and without past history of stroke were compared for significant events in the clinical course (e.g., Myocardial Infarction, Deep Vein Thrombosis, Pulmonary Embolism, acute stroke, cardiac arrest and mortality) using chi-square test. The mortality between these groups were compared stratified by age groups <18, 18-35, 36-65, 66-85 and >86 yrs.

Results 692 COVID-19 positive patients were admitted during this period, 93 (13%) had a past history of stroke. The mortality among patients with past history of stroke, 26 (28%) was higher than patients without past history of stroke, 85 (14%); p=0.001. Clinic Patients <35 years of age experienced <10% mortality while those >35 years of age had mean mortality of 25%. Among middle aged patients (36-65 years group), the mortality was six times higher (30%) when there was a past history of stroke compared to no past history of stroke (5%). The mortality among older patients (>66 years) was similar within these groups (~20%).Other significant clinical outcomes like Pulmonary embolism, cardiac arrest were not significantly elevated with past history of stroke.

Conclusions In this cohort of COVID-19 patients in our registry, a history of past stroke confers a high risk of mortality, which is especially high among middle aged patients. These results beckon further analyses to identify underlying pathophysiological mechanisms and biomarkers related to such age-specific mortality.

Authors/Disclosures
Naga Krishnakanth Madireddy, MD (Baptist Health Louisville) PRESENTER	Dr. Madireddy has nothing to disclose.
Saurav Das, MD (Washington University in St. Louis)	Dr. Das has nothing to disclose.
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Abstract Details