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Abstract Details

Structural Brain Network Implications of Cerebral Small Vessel Disease Burden Among Adults Living in Precarious Housing
Cerebrovascular Disease and Interventional Neurology
Cerebrovascular Disease and Interventional Neurology Posters (7:00 AM-5:00 PM)
148

This study aims to identify the effects of cerebral small vessel disease (cSVD) on structural brain network characteristics of homeless or precariously housed adults.
cSVD is the most common vascular contributor to dementia and is associated with increased risk of stroke and all-cause mortality. cSVD has been associated with damage to white matter tracts connecting regions within distributed brain networks in individuals with dementia, but the impact in younger, marginalized populations is not known.
The Hotel Study is an ongoing prospective study of a community-based sample of adults living in precarious housing or homelessness in Vancouver, Canada. Participants received T1, T2-FLAIR, DWI and SWI MRI sequences allowing characterization of cSVD burden with a modified score: one point for moderate-severe white matter hyperintensities (WMH), ≥1 cerebral microbleed (CMB), and ≥1 lacune (maximum three points). Sixty-eight cortical regions (nodes) were segmented from T1 scans using Freesurfer v6.0 and mapped onto diffusion space. Structural connectivity networks were derived from those regions based on BEDPOSTX model with two crossing fibres using probabilistic tracking approach in FMRIB Software (FSL v6.0.3). Graph-level and node-level network measures were computed using Brain Connectivity Toolbox. The final network measure comparisons were conducted by permutation inference of generalized linear models.
Participants (n=179 with complete imaging at baseline) were median age 45, with 79% identifying as male. For participants (n=74) with any burden of cSVD (score ≥1), 70% had moderate-severe WMH, 27% CMB, and 18% at least one lacune. Participants with cSVD burden demonstrated decreased network global efficiency (p=0.002), decreased small-worldness (p<0.001) and increased characteristic path length (p<0.001), without differences in modularity in both binary and weighted networks.

Presence of cSVD burden was associated with worse structural network efficiency in this young, precariously housed sample. Analysis of network features in cSVD may improve characterization of disease severity and modifiable risk factors.
Authors/Disclosures
Andrea Jones, MD, PhD (University of British Columbia)
PRESENTER 		Dr. Jones has nothing to disclose.
Lily Zhou, MD (Vancouver General Hospital) Dr. Zhou has received research support from Canadian Institute of Health Research.
No disclosure on file
No disclosure on file
Ghadeer Almomen, MBBS Dr. Almomen has nothing to disclose.
No disclosure on file
No disclosure on file
No disclosure on file
No disclosure on file
William Panenka, MD Dr. Panenka has nothing to disclose.
No disclosure on file
No disclosure on file
Thalia S. Field, MD (University of British Columbia) Dr. Field has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Bayer. Dr. Field has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Novartis. Dr. Field has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for AstraZeneca. Dr. Field has received personal compensation in the range of $500-$4,999 for serving on a Scientific Advisory or Data Safety Monitoring board for Boston Scientific. Dr. Field has received personal compensation in the range of $500-$4,999 for serving on a Speakers Bureau for AstraZeneca. Dr. Field has received personal compensation in the range of $5,000-$9,999 for serving as an Expert Witness for Canadian Medical Protective Association, plaintiff. The institution of Dr. Field has received research support from Vancouver Coastal Health Research Institute, Heart and Stroke Foundation of Canada, Brain Canada and CIHR. Dr. Field has a non-compensated relationship as a Editorial board with Stroke that is relevant to Â鶹´«Ã½Ó³»­ interests or activities. Dr. Field has a non-compensated relationship as a Editorial board with CJNS that is relevant to Â鶹´«Ã½Ó³»­ interests or activities. Dr. Field has a non-compensated relationship as a Editorial board with JNNP that is relevant to Â鶹´«Ã½Ó³»­ interests or activities. Dr. Field has a non-compensated relationship as a Board member with DESTINE Health that is relevant to Â鶹´«Ã½Ó³»­ interests or activities. Dr. Field has a non-compensated relationship as a Board Member with Vancouver General Hospital Foundation that is relevant to Â鶹´«Ã½Ó³»­ interests or activities.